Is a Five Marker Panel including Expression of Basal Markers (EGFR and/or CK5/6) compared to Three Marker Panel better in Predicting Prognosis in Molecular Subtypes of Breast Carcinoma?
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Abstract: Breast cancer shows marked heterogeneity which is proven by the fact that tumors with similar morphologic and immunohisto-chemical features show distinct clinical behavior and different response to therapy. This led to microarray-based global gene expression profiling (GEP) and new avenues for classifying breast cancer into molecular subtypes. Among all molecular subtypes, the worst prognosis group has been identified as triple negative phenotype (TN). Further within this group, basal like breast cancer (BLBC) was identified using a 5 marker surrogate panel including ER-PR-HER2–negative and basal markers i.e. epidermal growth factor receptor (EGFR) or Cytokeratin 5/6 (CK5/6) positive. EGFR and CK 5/6 are easily available and specific IHC surrogate basal markers and can be readily included in a five marker panel in prognostication of breast cancers. BME is not limited to triple negative subtypes but is also seen in other molecular subtypes. 106 cases of invasive breast carcinoma in which detailed clinical and histological prognostic factors could be determined were classified into molecular phenotype using IHC surrogate classification. Tumors expressing basal markers CK5/6 and EGFR were classified as basal marker expressing (BME) tumors and were also compared with ER, PR, Her-2/neu expressing and also triple negative tumors. These tumors were compared with various prognostic and predictive markers of invasive breast carcinoma. BME was seen in 50/106 cases. Also BME showed a significant association with tumor necrosis, lymph node metastasis and high histological grade. BME in breast carcinomas is an independent prognostic marker and its expression is not limited to triple negative cases. An expanded surrogate panel of ER, PR, Her-2 neu, EGFR and CK 5/6 provides more prognostic value than three panel marker. Keywords:Breast cancer, basal marker expression, triple negative, EGFR, CK 5/6
Authors and Affiliations
Trivedi Pawan, Varma Kachnar, Dhingra Vishal, Singh PremalaA, Misra Vatsala, Srivastva Sapan
A Study on Prevalence of Dyslipidemia in Obese Patients in a teaching hospital in Kerala
Obesity is an independent risk factor for dyslipidemia and Type2 Diabetes, both of which are inturn risk factors for coronary artery disease and stroke,and is rising in prevalence throughout the developed and developing...
Effects of Soy-flour Enriched Diet on the Testis and Gonadal Hormone Status of Male Wistar Rats
This study was designed to determine the effects of soy-flour enriched diet on the testis morphology, gonadal hormones (Testosterone and FSH) and accessory sex glands (prostate and seminal vesicle) semen count and motili...
Study of insulin secretory response after oral glucose load in smokers
Abstract: The objective is to study of insulin secretory response after oral glucose load in smokers.Study was conducted on normal BMI matched healthy 40 nonsmokers and 60 smokers (divided into 3 groups according to amou...
Assessment of Organs Dose to Patients Undergoing Skull X-Ray Examinations
This study was done in two hospitals in Sudan in Khartoum state to assess organ dose to patient undergoing skull x-ray. The CAL-Dose software was used for calculations of entrance surface air kerma (ESAK) and organs dose...
Introduction of A Unique Medical Co-Operative System for Decompression Sickness in Izu Peninsula
We describe our attempts to form a co-operative system for patients with decompression illness (DCI). We selected the narrative method concerning the distribution of fire departments, medical control systems, the coast...