Is the ratio of pseudocholineaterase levels in pleural fluid to serum a new parameter
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 6
Abstract
Background and objectives: Pleural effusion is a common clinical condition faced in everyday practice. The first step in the management of pleural effusion is its differentiation into transudates and exudates. Light’s criteria is the most widely used parameter to differentiate pleural effusions but studies have shown that Light’s criteria misclassifies a significant amount of cases. Objectives:To study the levels of Cholinesterase in pleural fluids of diverse etiologies,To evaluate the validity of pleural fluid cholinesterase (ChE) and its ratio with serum cholinesterase in order to differentiate between transudates and exudates, To compare this diagnostic efficacy with Light’s criteria Methods: The study was conducted in Hangal Shri Kumareshwar Hospital attached to S. Nijalingappa Medical College, Bagalkot. Study included 125 patients who had pleural effusion who met the inclusion and exclusion criteria. Duration of the study was 12 months. Results: 62 cases (50%) had transudative effusion and 63 cases (50%) had exudative effusion. The mean PChE levels in transudates was 806.26 + 516.28 U/L and in case of exudates it was 3476.11 + 1250.17 U/L. The difference between the two groups was statistically significant (p-value < 0.05). Accordingly the mean value of this ratio was 0.10 + 0.05 in the transudates group and 0.39 + 0.14 in the exudates group. This difference was found to be statistically significant (p-value <0.001). This ratio misclassified 5 cases. Among them 2 (3.2%) were transudates that were misdiagnosed as exudates and 3 (4.8%) were exudates that were misdiagnosed as transudates. In this study Light’s criteria misclassified 13 cases in total with a sensitivity of 91.9% and a specificity of 87.3%. Conclusions: Light’s criteria has a good sensitivity and specificity but P/S ChE was the most efficient parameter in differentiating between transudates and exudates in this study.
Authors and Affiliations
Dr Gopal Bajaj, Dr. Mangalvedi Vikram Vadiraja, Dr. Udit Agarwal
Keywords
Related Articles
- EP ID EP375755
- DOI 10.9790/0853-1706030408.
- Views 68
- Downloads 0
Profile And Risk Factor Analysis Of Biopsy Proven Acute Rejection& Role Of Basiliximab In Tacrolimus Era - A Multicentric Study:
Aim & Objective: To study the incidence, various risk factors of acute rejections and to show any role of induction agent (Basiliximab) & type of CNI regimen on the incidence of acute rejections. Materials & methods: We...
QT Dispersion-An Ignored Screening Tool For Cardiovascular Disease In Diabetics
Background: Diabetes Mellitus Type 2 is a major global non-communicable disease among adults causing micro and macrovascular complications, one being cardiovascular system. QT dispersion represents the summation of sever...
Prevalence of Nonmotor Symptoms in Parkinson’s Disease
Non motor symptoms(NMS) in Parkinson’s Disease constitute a major clinical challenge, as they are common,yet often overshadowed by the dominance of motor symptoms and high unawareness of these among treating health care...
Airway Management in An Adult Patient with A Large Vallecular Cyst: A Case Report
Abstract Vallecular cysts are rarely seen in adults and occur as a result of the tongue base mucus retention. In cases with laryngeal inlet obstruction due to a vallecular cyst, the airway management sometimes might be a...
Subclinical Hypothyroidism in type 2 diabetes mellitus patients
Introduction: Diabetes mellitus (DM) is the most common metabolic disease and its prevalence is increasing rapidly. Studies have reported that there is thyroid dysfunction in Type 2 Diabetes Mellitus patients. Subclinica...