Isobolographic analysis of ototoxic interactions between gentamicin and furosemide in mice — preliminary report
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 3
Abstract
SUMMARY Aminoglycoside antibiotics and loop diuretics have long been known to have ototoxic effects. However, characteristics of pharmacodynamic interactions of these drugs are stil) not recognized. In the presented study, the isobolographic analysis was used, which is an experimental, mathematical-statistical model of evaluation of pharmacological interactions between drugs, given in different fixed and definite combinations. Gentamicin in a dose of 400 mg/kg, furosemide in a dose of 100 mg/kg and their combination at the fixed-ratio of 1:1 were injected intraperitoneally to Albino Swiss mice. Auditory brainstem responses were used to assess the hearing threshold at 15 and 30 min after the drug injections. The combination of gentamicin with furosemide resulted in synergistic interaction. Results of presented work prove that the isobolo-graphic analysis is very precious and usefull to estimate types of interaction of ototoxic drugs. It gives new possibilities in the recognition of mechanisms of action of ototoxic drugs and in prevention of ototoxicity.
Authors and Affiliations
Marek Zadrożniak, Marcin Szymański, Kamal Morshed, Henryk Siwiec, Janusz Klatka, Jarogniew Łuszczki
Keywords
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