ISOLATION AND IN VITRO ANTIOXIDANT ACTIVITY OF FLAVONOID FROM LINDERNIA CRUSTACEA (L) F. MUELL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: The objective of the study was to investigate the antioxidant property of different extracts of Lindernia crustacea (L) F. Muell and isolate flavonoid from the potent extract and characterize it. Methods: Isolation was carried out by flash chromatography using Toluene:acetic acid (4:1) as eluent. The isolated compound was characterized using spectroscopic methods. 2, 2′- diphenyl-1-picrylhydrazyl, ferric thiocyanate, thiobarbituric acid, and reducing power assay methods were followed for the antioxidant study. Results: Characterization of the isolated compound confirms it as the flavonoid. Results of the antioxidant study showed that benzene extract has the highest antioxidant activity with a less IC50 value in comparison to ethyl acetate and ethanol extracts. The isolated compound showed significant antioxidant activity when compared with aspirin. Conclusion: The results of the study suggest that L. crustacea (L) F. Muell is a source of flavonoid which has potent antioxidant activity.
Authors and Affiliations
SMRITI REKHA CHANDA DAS , ABDUL BAQUEE AHMED , DIBYENDU SHIL , INDRANIL CHANDA
Keywords
Related Articles
- EP ID EP609000
- DOI -
- Views 109
- Downloads 0
NEUROPROTECTIVE EVALUATION OF LAGENARIA VULGARIS EXTRACT HYPOXIC NEUROTOXICITY INDUCED RATS
ABSTRACTObjective: The present study was aimed to evaluate the neuroprotective effects of Lagenaria vulgaris seed oil (LVSO) in hypoxic neurotoxicity inducedneurodegeneration in mice.Methods: Hypoxia was induced by provi...
GREEN SYNTHESIS, CHARACTERIZATION, AND IN VITRO ANTIMICROBIAL EFFICACY OF SILVER NANOPARTICLES SYNTHESIZED FROM TECTONA GRANDIS WOOD FLOUR
Objective: Silver nanoparticles (AgNPs) are widely used as an antimicrobial agent. Due to the toxicity concerns related to the synthesis of the AgNPs, there is an urgent need of the novel green techniques to synthesis th...
VASOPROTECTIVE EFFECT OF PHYSALIS ANGULATA L. LEAF WATER EXTRACT ON KIDNEY OF NΩ-NITRO-L-ARGININE METHYL ESTER-INDUCED ENDOTHELIAL DYSFUNCTION RAT MODEL
Objective: This study was to investigate the effect of Physalis angulata L. leaf water extract on vascular rarefaction, oxidative stress, and inflammation on the kidney of Nω-nitro-L-arginine methyl ester (L-NAME)-induc...
FORMULATION AND OPTIMIZATION BY APPLYING 32 FULL FACTORIAL DESIGN OF MUCOADHESIVE MICROSPHERES OF NIFEDIPINE
Objective: The purpose of this research work is to formulate and optimize mucoadhesive microspheres of nifedipine using Carbopol 934P as mucoadhesive and ethyl cellulose as a carrier polymer for controlling the release o...
UTILITIES AND LIMITATIONS OF CURRENT ANIMAL MODELS OF DEPRESSION
  Depression is one of the most debilitating medical conditions in the world today, yet its etiologies remain imprecise, and current treatments are not wholly helpful. Depression is more than just a feeling of sadness....