ISOLATION, IDENTIFICATION AND CHARACTERIZATION OF 20(29)-LUPEN-3-OL FROM THE ROOT EXTRACT OF DACRYODES EDULIS AND ITS ANTIMICROBIAL POTENCIES AGAINST SOME CLINICAL AND PLANT PATHOGENS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 7
Abstract
Roots of Dacryodes edulis are used in traditional medicine as remedy to stomach ailment, parasitic skin diseases, dysentery and yellow fever. This study was aimed at isolation and characterization of pure compound that enhances the medicinal potency of the plant part by means of spectroscopic methods which include Thin Layer Chromatography, FT-IR, nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR and 2D) as well as the antimicrobial activity of the isolated compound against some clinical and plant pathogens. 20(29)-lupen-3-ol was isolated from the plant and its antimicrobial activity was examined on 6 bacteria and 11 fungi and also 4 standard control drugs were used in the study. The antimicrobial screening of the isolated compound showed that the compound has higher potential for medicinal values. The compound exhibited high activity against some of the microbes used. It was sensitive to Aspergillus flavus, Aspergillus fumigates, Coniophora puteana, fibrophoria vaillentii, fasarium proliforatum, Rhizopus sp, Serpula lacryneus with zones of inhibition 32, 30, 27, 28, 29, 30, 28mm respectively. The antibacterial screening shows that the compound was sensitive against Methicillin resist staph aureus, staphylococcus aureus, Escherichia coli and Salmonella typhi with zones of inhibition 30, 27, 28 and 27mm respectively. The results accounts for the trado-medical claims of the plant and thus could be used as a candidate of drug in curing some diseases caused by the microorganisms examined in the study.
Authors and Affiliations
Nna P. J.
Keywords
Related Articles
- EP ID EP672581
- DOI -
- Views 131
- Downloads 0
ANTIMICROBIAL ANALYSIS OF POLYHERBAL FORMULATION LINKUS COUGH SYRUP
The Herbal products has widely use throughout the globe since 5,000 years. The objective of this study is to determine the antimicrobial analysis of Polyherbal formulation Linkus cough syrup and its comparison with the o...
CRISPR GENOME EDITING
CRISPR genome editing is a revolutionary technique which made major changes in biological science. It is a part of prokaryotic immune system. When prokaryotes attacked by viruses, they resist the virus with the adaptive...
A REVIEW ON: IMPLIMENTATION OF YOGIC DIET IN TODAY’S ERA
We don’t eat to be healthy, we don’t eat to live better, we just eat for taste. So, don’t make your body a graveyard or a junkyard. Keeping this in mind Acharya Charaka has stated three sub pillars of the body- Aahara, N...
NASAL DRUG DELIVERY SYSTEM-A NOVEL APPROACH
Faster and higher level of absorption is done by nasel mucosa which is a potential administration route. Inrecent years many drugs have been shown to achieve better systemic bioavailability through nasal route than by or...
CLINICAL DIAGNOSTIC METHODS AND MANAGEMENT OF TOBACCO CHEWING ADDICTION THROUGH AYURVEDA
Tobacco Addiction is the leading cause of cancer in all over the world including India. In Ayurveda the Tobacco Addiction and its toxicity has been already mentioned since Nighantu-kala along with its properties and ther...