Isolation of Apigenin Derivatives from the Leaves of Chorisia speciosa, Cordia dichotoma, Mentha piperita and Roots of Pluchea lanceolata

Apply

Isolation of Apigenin Derivatives from the Leaves of Chorisia speciosa, Cordia dichotoma, Mentha piperita and Roots of Pluchea lanceolata

Journal Title: Tropical Journal of Natural Product Research - Year 2017, Vol 1, Issue 2

Abstract

Apigenin (4′,5,7-trihydroxyflavone) is a plant-derived skin cancer chemopreventive flavonoid that has anti-allergic, anti-depressant, anti-inflammatory, antimetastatic, antioxidant and anti-cancer properties. Our study was planned to isolate the apigenin derivatives from the leaves of Chorisia speciosa A. St. Hil.(Bombacaceae, Malvaceae), Cordia dichotoma G. Forst. (Boraginaceae) and Mentha piperita L. (Lamiaceae) and the roots of Pluchea lanceolata (DC.) C. B. Clarke (Asteraceae). The air-dried plant materials were exhaustively extracted with methanol in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel (60-120 mesh) for the preparation of slurries. The dried slurries were chromatographed over silica gel columns individually. The columns were eluted with petroleum ether, chloroform and methanol, successively, in order of increasing polarity to isolate the apigenin derivatives. Phytochemical investigation of the methanol extract of the leaves of C. speciosa afforded β-sitosterol 3-β-Lglucopyranoside (1) and apigenin 4′-O-α-L-glucopyranosyl-(6′′→1′′′)-α-L-rhamnopyranoside (2). Column chromatography of the methanol extract of the leaves of C. dichotoma gave α-L-arabinose (3), β-D-arabinose (4) and acacetin-7-O-β-D-glucopyranosyl-(6a→1b)-O-β-D-glucopyranosyl- (6b→1c)-O-β-D-glucopyranosyl-2c-linolenate (5). The methanol extract of the leaves of M. piperita on subjection to silica gel column furnished 5-hydroxy-6, 7, 3′, 4′-tetramethoxy-8-(1′′- gerananyl)-flavone or 8-(1′′-gerananyl)-5-demethylsinensetin (6) and 3′,4′-dihydroxy-β-phenyl ethyl caffeate-4-(3′′′-menthyl)-4′-β-D-glucopyranoside or 4-(3′′-menthyl) teucrol 4′-O-β-Dglucoside, 7). The chemical constituents isolated from the methanol extract of the roots of P. lanceolata included n-tridecyl stearate (8), n-nonadecanol (9) and 8-isobutyl apigenin (10). Apigenin derivatives were isolated from the investigated medicinal plants. Their structures were established on the basis of spectral data analysis and chemical reactions.

Authors and Affiliations

Mohammed Ali

Keywords

Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils

Received 30 December 2017 Revised 02 February 2018 Accepted 05 February 2018 Published online 07 February 2018 This work is aimed at producing an effective self-emulsifying nanoformulation of a combination of 9 antimic...

Modulation of Cytokines by Ketogenic Diet and Cyclophosphamide Chemotherapy in 1-Methyl Nitrosourea-Induced Mammary Tumour in Rats

Received 02 November 2018 Revised 17 November 2018 Accepted 24 November 2018 Published online 27 November 2018 Cancer is the second leading cause of death worldwide and it is expected to increase fivefold in the next 25...

EP ID EP349927
DOI 10.26538/tjnpr/v1i6.4
Views 111
Downloads 0