KIKUCHI-FUJIMOTO DISEASE (HISTIOCYTIC NECROTIZING LYMPHADENITIS): A CASE REPORT
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 4
Abstract
Kikuchi-Fujimoto disease (KFD) is a self-limited pathological entity that is benign in its course. The main features of this disease are tender regional cervical lymphadenopathy, usually accompanied by low-grade fever and night sweats. Less frequently patients may report weight loss, nausea, vomiting, and sore throat. Often referred to as KFD; Kikuchi-Fujimoto disease has a global prevalence with high report rates from Japan and other Asian regions. That said, it is a very uncommon case to encounter due to its rare occurrence. A viral causation is suggested keeping in view the clinical presentation, the histology and immunohistochemical pattern. The recommended procedure to diagnose this disease is an excisional biopsy of an affected lymph node. This histopathologic analysis is essential for the clinician to differentiate it from similarly presenting conditions like tuberculous lymphadenitis (scrofula), lupus (SLE) or malignant lymphoma to state a few. This is especially pertinent in regions where there is a high index of suspicion for tuberculosis given its high prevalence, like Pakistan and India for example. It is also essential to inculcate an understanding of this clinically and histopathologically challenging disease amongst physicians and pathologists alike to decrease the risk of misdiagnosis. Steps to increase awareness will also help curb the excessive costs and unnecessary interventions that go with wrong diagnoses. In young patients who present with lymph node enlargement in the posterior cervical chain; a biopsied node showing cellular and nuclear fragmentation along with features of necrosis should incite the consideration of KFD amongst other differentials. Once diagnosed; symptomatic treatment with NSAIDs, analgesics, antipyretics and in some cases corticosteroids is sufficient as the self limited disease resolves by itself within a period of 1 month in most cases. It is unlikely to stretch beyond 4 months. Patients with KFD are followed for many years nonetheless, since these patients are at a slightly increased risk of developing systemic lupus erythmatosus later in life than the general population. The case we report is that of an 18 year old female patient who presented with a month history of low grade fever, night sweats and cervical lymphadenopathy, which was minimally tender. She was initially labeled as a case of tuberculous lymphadenitis and put on antituberculous therapy. However, she did not respond and further diagnostic studies revealed the presence of KFD.
Authors and Affiliations
Saleem Nasir| Training Medical officer (Resident), Medicine, Hayatabad Medical Complex, Peshawar, Pakistan, Corresponding author email: nasirsaleems@hotmail.com, Mubbasher Ameer Syed| Medical officer, Peshawar Health Clinic, Peshawar, Pakistan
Keywords
Related Articles
- EP ID EP11100
- DOI 10.5958/j.2319-5886.2.4.168
- Views 322
- Downloads 16
Measurement of the Patulin toxicant using high performance liquid chromatography (HPLC) in apple juices supplied in Khorramabad City, Iran
Making use of low quality moldy and worm-eaten fruits for juice production causes various irritations in human body due to its hazardous compounds. Today, Patulin toxicant is one of the most important compounds to be i...
The Pattern to Predict Social Phobia Based On Social Self-Efficacy, Shyness and Coping Style in the Secondary School Students
The aim of this study was to determine predictors of social phobia through studying some social phobias predictors. In this study, shyness, social self-efficacy and coping styles were assessed as predictors of social ph...
PREVALENCE OF HEALTH CARE ASSOCIATED INFECTIONS IN A TERTIARY CARE HOSPITAL IN DAKSHINA KANNADA, KARNATAKA: A HOSPITAL BASED CROSS SECTIONAL STUDY
Background: Health Care-Associated Infections (HCAI) affect millions of people each year and raise a great risk for patients in health care settings, leading to high rates of morbidity and mortality. Objective: To estim...
Investigating the effect of home care program on self-efficacy of femaleheaded single-parent households supported by Isfahan Welfare Organization (Behzisti) in year 1394
Introduction: Female-headed households are among the most vulnerable groups of society and there are potential of many critical jeopardies for these families. Therefore, this study was focused to evaluate the effect of...
Anaesthetic Management of a Case with Congenital Complete Heart Block Posted for Lower Segment Caesarean Section
Complete heart block in pregnancy is relatively a rare problem. It may be congenital or acquired. Congenital complete heart block may be asymptomatic. Acquired causes may be secondary to cardiac surgery, rheumatic heart...