L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 8
Abstract
Background: L-arginine is a multifactorial compound, indirectly involved in multiple regulatory mechanisms substrate for nitric acid synthesis. It has been documented that it has a beneficial effect on insulin resistance in Type 2 Diabetes (T2D) and visceral obesity. Experimental and clinical trials have illustrated the undergoing mechanistic pathways either on molecular or biochemical levels. However, the relationship between L-arginine supplementation and insulin receptor expression has not elucidated. Aim: The study aimed to evaluate the influence of L-arginine supplementation on insulin receptor expression, insulin resistance and weight gain in high fat diet fed rats. Subjects& Methods: 48 female albinos with visceral obesity were randomly assigned to either receive a high fat diet for 12 weeks or L- arginine with a dose of 5% in food for the last 8 weeks. Two age groups were enrolled ?adult and old?, Biochemical analysis was performed including: the concentration of insulin receptor expression in visceral fat, plasma insulin receptor and fasting blood glucose, the insulin resistance was evaluated according to the homeostasis model assessment- insulin resistance (HOMA-IR) protocol. Results: The concentration of insulin receptors was significantly higher in L-arginine treated group and associated with significant decrease in HOMA_IR and insulin concentration. In addition, the influence of L-arginine is conversely proportional with age. Conclusion: our results supports the hypotheses that dietary L-arginine supplementation results in increase insulin receptors, which could lead to negative feedback on insulin resistance.
Authors and Affiliations
Nashwa EL-Khazragy, Dalia A. Saad.
Keywords
Related Articles
- EP ID EP633986
- DOI 10.21474/IJAR01/9551
- Views 49
- Downloads 0
CORRELATION OF PREOPERATIVE IOL POWER WITH THE POSTOPERATIVE REFRACTIVE STATUS IN SENILE CATARACT.
Aim of study-To correlate preoperative IOL power and postoperative refractive status in patients operated for senile cataract admitted to department of Ophthalmology in a tertiary health care centre MATERIAL AND METHODS...
A METHOD OF IMPROVING DETECTION RATIO THROUGH CLUSTER SECURITY THRESHOLD MANAGEMENT IN CFFS.
Today, security is becoming more important as more WSN applications are developed. In a sensor network, an attacker can easily physically acquire and compromise the node, and such threats can be used to inject false repo...
IMPLEMENTATION STUDY OF ACCRUAL-BASED ACCOUNTING IN REGIONAL GOVERNMENT ENTITIES.
This research was conducted with the aim of analyzing and reviewing the implementation of accrual?based accounting in local government entities. In the first year, the study was conducted in the form of instruments monit...
OVERWEIGHT PREVALENCE AMONG ELEMENTARY SCHOOLS PUPILS IN THE CITY OF IASI, ROMANIA.
This study represents the result of a research on a population aged between 11 and 15 years, respectively pupils attending elementary schools in the city of Iasi (8911). The research aimed at emphasising cases of overwei...
FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND MULTIPLE MYELOMA.
Focal segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal disease in the United States. FSGS is more prevalent in young African American patients. It is commonly associated with var...