La thyroglobuline plasmatique chez la femme enceinte à Lubumbashi Analyse de son profil et de ses relations avec la TSH, l’Iode urinaire et la ferritine
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: indicators for iodine nutrition stutus are goiter rate, urinary iodine excretion and rate of household using iodide salt. Thyroglobulin has been used as a biomarker for iodine status mainly in children. No data in our area exist for pregnant women. This study aimed to determine thyroglobin profil during pregnancy and its variations according other parameters such TSH, urine iodine and Serum ferritin Method: cross sectional study including 225 pregnant women at first, second and third trimester. We collected urine samples in sterile box for iodine assay using ammonium persulfate method. TSH, Ferritin and thyroglobulin was measured in serum by immunoanalysis assay. Statics was done using Epi-info 7 and Execl, with the significance threshold of 0.05; Results: the trend of thethyroglobulin was to increase with gestational evolution (r=0.18, p=0.04). There was a significant difference betweenthyroglobulin median during trimester: 9.2 ng/ml (3.5-16.5 ng/ml) at first trimester, 14.2 ng/ml (7.2 – 23.7 ng/ml) at the second trimester and 16 ng/ml (7.3- 25.4 ng/ml) at the third trimester. 52% of pregnant women had low iodine urine excretion (<150 µg/l) with 23% of them having less than 50 µg/l). In the presence of Iodine deficiency, the thyroglobulin median was high. The trend of thyroglobulin was to decrease when iodine status was normal and to increase when TSH level was upward; it increased too when ferritin level was low. Conclusion: thyroglobulin seems to be a good iodine status biomaker good biomarker among pregnant women and it’s reflect good thyroid gland adaptation to incoming iodine nutrition
Authors and Affiliations
Eugène Twite Kabange, Laurence Habimana, Jean Mbuya Katenga, Pierre Bernard, Etienne Mpoyo Kasongo, Philippe De Nayer, Damien Gruson, Philippe Donnen, Prosper Kalenga Muenze, Annie Robert
Keywords
Related Articles
- EP ID EP467661
- DOI 10.9790/0853-1802124956.
- Views 57
- Downloads 0
Fulminant Hepatic Failure: Clinical Spectrum & Outcome
Introduction: Present study was conducted to assess the demographic characteristics, risk factors, causative spectrum, clinical features, natural course and outcome in patients of fulminant hepatic failure. We also tried...
Correlation of Obesity Indices with Blood Pressure and Blood Glucose Level among Young Medical Students
Overweight and obesity are affecting both developed and developing countries. WHO has declared obesity as a disease of pandemic significance Objectives To assess the relationship of obesity indices with blood pressure an...
In vitro antibacterial analysis of copper solution (microparticle) – a novel anti-infective molecule for wound management
Now a days the emergence of antibiotic resistant bacterial pathogens are considered as the major alarm, there is a need to concentrate on the synthesis of new antibacterial agents. Most of the public getting aware about...
Evaluation of Post Tracheostomy Tube Care in the Tertiary Care Centre
Background and objectives : Tracheostomy is making an opening in the anterior wall of trachea and converting it into a stoma on the skin surface.Adequate tracheostomy care is required to prevent complications in the post...
Immunohistochemical Association of HER-2 /Neuimmunoprotein with HistomorphologicalVariables in Patients in Gastric Carcinoma.
Gastric tumour is the fourth most common cancer and the second leading cause of death due to cancer worldwide. Gastric cancer is more common in male than in female in the ratio of 2:1. It is a disease of elderly. The his...