Lactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure
Journal Title: Journal of Pharmaceutical & Health Sciences - Year 2017, Vol 5, Issue 2
Abstract
Introduction. Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease. Patients with chronic kidney disease (CKD) face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function. Lactulose is a hyper osmotic agent and as a prebiotic could reduce serum urea and potassium levels and have some effects on fluid overload. The aim of this study was to evaluate effect of lactulose on serum levels of biochemical products in patients with CKD. Materials and Methods. In this prospective before-after intervention study 17 patients with end stage of CKD ( 76.47 % men; mean age 65.88 ± 13.4) were evaluated. All patients received lactulose, 10 ml, 3 times per day for 3 months. Blood samples from all participants were collected before and at the end of intervention to examine changes in biochemical parameters, including potassium, urea, creatinine and uric acid. A P value less than 0.05 was considered significant. Results. Lactulose significantly decreased urea levels (p=0.001), blood potassium (0.001) and fluid overload (with due attention to patient’s weight p=0.001) in patients with end-stage renal failure. The decrease in serum creatinin and uric acid were not significant. Conclusions. Lactulose administration in CKD patients could decrease levels of various deleterious elements especially urea and blood potassium, The daily use of lactulose in CKD patients e suggested in order to receive better therapeutic results.
Authors and Affiliations
Negin Aleagha, Farahnaz Pasha, Maryam Shiehmorteza
Keywords
Related Articles
- EP ID EP214506
- DOI -
- Views 184
- Downloads 0
Lactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure
Introduction. Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease. Patients with chronic kidney disease (CKD) face with uremic toxins and hyperkalemia. Also...
Physicochemical characteristics and storage stability of clarified butter fat « smen » produced from pasteurized and non-pasteurized milk
Smen is a milk fat isolated by ‘boiling-off’ water. Milk fat was first converted into butter and then into smen. Smen product is utilized for culinary cooking and frying of different food. Smen has better shelf-life than...
Physicochemical Analysis of Margarine, Butter and Butter Oil Samples of Iran’s Markets
Butter, margarine and butter oil are three products which consume daily by Iranian community. Detection of type and existence of synthetic antioxidants (SAs) quantities in the margarine, butter, and butter...
Comparison the effect of carboxymethyle cellulose films containing Thymus vulgaris and Zataria multiflura on shelf life of chicken meat
Poultry meat is a kind of perishable food. The growth of pathogenic microorganisms may occur in chicken meat during storage in the refrigerator. Microbial growth causes a serious hazard to the safety of the food consumer...
Antifungal effects of crude extract and fractions of Euphorbia splendida Mobayena gainst Aspergillus niger, Aspergillus fumigatus, Candida albicans and Candida krusei
The significant decline in infectious diseases was owed to the development of the antibiotic industry. Due to the prevalence of drug-resistant organisms alongside the other problems, scientists have been focused on med...