Langerhans Cell Histiocytosis: A Case Report and Review
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Langerhans’cellhistiocytosis (LCH) (Histiocytosis X) is a rare disease of unknown cause characterized by oligoclonal proliferation of Langerhans cells. It occurs mostly in children and young adults and involves one or more body systems such as bone, hypothalamus, posterior pituitary gland, lymph nodes, liver or various soft tissues. Owing to the relative rarity of the condition, it remains a disease in which the diagnosis is often delayed or missed and in which many questions remain unanswered, ranging from etiology and pathogenesis to therapy. This case report would increase the awareness of pediatric dentists about the dental manifestations and multisystem involvement in LCH. Key Words: LCH, histiocytes, Punched out lesions of bones. Case Report: 5 year old boy was brought to our hospital with chief complaint of loose teeth, gingival swelling left facial swelling and left ear discharge since 3 months. The problem had started with a feeling of all teeth becoming loose 3 months ago. The swelling of gums and left facial region started 3 weeks before followed by left ear discharge. Physical examination: Extra – oral: Diffuse, mild swelling on left lower third of face with overlying erythematous surface (Figure 1). Intra – oral: 1. Localised ulceration of size 3×2cm with indistinct borders on alveolar ridge of 74, 75, 36 and 84, 85, 46 region. 2. Grade III mobility of 81, 82, 83 and 84. Orthopantomogram: 1. Extensive lytic lesions with ill-defined, irregular margins involving the mandible extending from 46 region continuously till left coronoid notch and almost whole left ramus of mandible (Figure 2). 2. Floating teeth in air appearance of 71, 72, 73, 74, 36, 81, 82, 83, 84 and 46. Lateral skull radiograph: Multiple punched out lesions of skull (Figure 4, 6). Lateral view of mandible: Lytic lesions of body and ramus of mandible (Figure 3, 5).
Authors and Affiliations
Dr Bhawna Gautam, Suchithra MS, Amit Aneja
Keywords
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- EP ID EP238369
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