Langerhans’ Cells may linked to neuro-immuno-modulation
Journal Title: Journal of Neurological Sciences-Turkish - Year 2007, Vol 24, Issue 1
Abstract
The cutaneous cells bearing Paul Langerhans’ eponym were first described by him in 1868. These cells have remained mysterious for a very long time; as late as 1974, Montagna and Parakkal could state that “their origin remains somewhat obscure and their function is completely unknown.” Langerhans’ cells (LC) play an important role in the induction of contact hypersensitivity and graft rejection. These antigen presenting cells are modulated by various physicochemical agents (such as UV light, in my opinion acupuncture) and can be infected by the AIDS virus. Recent studies also reveal that cytokines mediate their development into potent T cell-stimulatory dendritic cells. Thus, we may well use LC for stimulating nervous system regulatory network as Paul Langerhans stated almost 140 years ago.
Authors and Affiliations
Nezih Oktar
Keywords
Related Articles
- EP ID EP128864
- DOI -
- Views 90
- Downloads 0
Parkinson Hastalığında Bellek Fonksiyon Bozukluğu
Yapılan nöropsikolojik çalışmalarla İdiyopatik Parkinson Hastalığında (İPH), motor semptomlarla beraber belirgin kognitif yıkım da olduğu gösterilmiştir. Nörodavranışsal yetiler içinde en çok etkilenenlerden biri bellek...
Granulocyte-Macrophage Colony-Stimulating Factor-Driven Microglia Contribute To Initiation or Sustaining of Experimental Autoimmune Encephalomyelitis
Although not well understood, the elimination and expansion of T cells in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) is governed by a complex interplay between infiltrated immune...
Epilepsilerin Genetik Yönü ve İdyopatik Epilepsi Genetiğinde Son Gelişmeler
Epileptik sendromların temelinde kromozomal bozukluklar, tek gen defektleri ve büyük çoğunlukla da kompleks kalıtım gibi farklı genetik geçiş şekilleri yatmaktadır. Epilepsinin diğer nörolojik ve sistemik bulgulara eşlik...
The ARG399GLN Polymorphism in DNA Repair Gene XRCC1 Does Not Alter Risk of Parkinson's Disease
The etiology of Parkinson's disease (PD), a neurodegenerative disorder, is still unknown and the role of genetic factors have been implicated. XRCC1 (X-Ray Repair Cross-Complementingin) protein is required for DNA single...
The Validity and Reliability of The Turkish Version of The Quality of Life Scale For Patients With Alzheimer's Disease (QOL-AD)
Objective: QOL is a multidimensional concept set as indicator to assess the effect of interventions applied to the Alzheimer patients. The objective of this study is to assess the validity and reliability of the Quality...