Large and micro coronary vascular involvement in diabetes.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue
Abstract
Diabetes, with hyperglycemia as its hallmark, is a major risk factor forischemic heart disease. The role of coronary disease in the adverse prognosis of diabetes is controversial although the higher prevalence and extension of coronary atherosclerosis is well recognized. The paper reviews the available evidence of coronary involvement in diabetes with particular emphases on microcirculation. Several studies, mainly in type 2 diabetes, have documented a reduced coronary flow reserve even in absence of coronary obstructive disease and using different techniques. Microcirculatory dysfunction affects the left ventricle globally as well as regionally. However, neither the prevalence of such abnormality in the diabetic population nor its time course and its prognostic value have been investigated in specifically addressed studies. In fact, a relatively large number of studies on myocardial perfusion performed bysingle-photon myocardial scintigraphy in asymptomatic diabetics rather address the problem of the prevalence of silent ischemia and its prognostic value. In spite of such limitation it can be speculated from the few available studies with known coronary anatomy that the prevalence of exclusively regional disturbances of perfusion (scintigraphic defects) in absence of obstructive coronary disease is not marginal as it ranges from 11 to 63%. Extensive research is still required to define the pathogenesis and the actual clinical relevance of coronary microcirculatory dysfunction in diabetes.
Authors and Affiliations
Antonio L\'Abbate
Keywords
Related Articles
- EP ID EP118299
- DOI -
- Views 91
- Downloads 0
Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.
Background: Expression of drug-metabolizing enzymes and drug transporters in liver is mainly regulated by a system of nuclear receptors. The aim of the current study was to investigate the expression of nuclear receptors...
Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice.
The aim of the present study was to examine the effect of mirtazapine (MIR) and risperidone (an atypical antipsychotic drug), given separately or jointly, on immobility time in the forced swimming test in male C57BL/6J m...
Lymphocyte-suppressing, endothelial-protective and systemic anti-inflammatory effects of metformin in fenofibrate-treated patients with impaired glucose tolerance.
Background: No previous clinical study has been designed to assess the additive effect of metformin and a fibrate on lymphocyte secretory function. The aim of our study was to investigate whether metformin produces any e...
Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain.
Three derivatives of dihydrofuran-2-one (L-PP, L-PP1, and L-SAL) were administered by intraperitoneal injection and their analgesic activity was assayed in several models of pain. The activity of these derivatives were t...
Central effect of histamine in a rat model of acute trigeminal pain.
In conscious rats implanted with an intracerebroventricular (icv) cannula, effect of icv injections of histamine, chlorpheniramine (H(1)-receptor antagonist) and ranitidine (H(2)-receptor blocker) was investigated in a r...