Late-onset restless legs syndrome evaluated at night-hours with resting-state fMRI of the brain and voxel-based morphometry
Journal Title: Hellenic Journal of Radiology - Year 2018, Vol 3, Issue 1
Abstract
Purpose: The aim of the study was to investigate the resting state networks and brain volumetric changes in patients with late onset restless legs syndrome (lRLS). Material and Methods: Nine untreated lRLS patients (mean age 65.2 +/- 7.7; mean disease duration 4.2 +/- 2.6 years) and 9 age and sex matched controls were evaluated at night hours with resting state fMRI (rs-fMRI) and a 3D T1-weighted sequence. The evaluation of rs-fMRI data was performed using the independent component analysis model. Volumetric changes were evaluated with voxel based morphometry (VBM). Results: The fMRI analysis revealed eight resting state networks. Patients compared to controls showed significant greater activation of the supplementary motor area and the premotor cortex in the right hemisphere. VBM analysis did not reveal any significant volume change in brain white and grey matter. Conclusions: Untreated patients with lRLS do not have any regional brain volume alterations. Activation in the presymtomatic period of the supplementary motor cortex and the premotor cortex may represent anticipation of the forthcoming sensorimotor symptoms.
Authors and Affiliations
Persefoni Margariti, Panagiota Spyridonos, Loukas G. Astrakas, Vassileios Xydis, Spyridon Konitsiotis, Maria I. Argyropoulou
Keywords
Related Articles
- EP ID EP373617
- DOI -
- Views 144
- Downloads 0
A young woman with dysarthria, bradykinesia and ataxia
A 23-year old female presented in the Emergency Department with dysarthria, bradykinesia and ataxia. The patient inhaled heroin one week before the onset of the symptoms. She was tachypnoeic but haemodynamically stable (...
Reducing patient’s psychological stress. A guide for MR technologists
When performing magnetic resonance imaging (MRI) in the clinical setting, the patient experiences many psychological issues, mainly due to the nature of the examination, the structure of the magnet and the anxiety relate...
An Introduction to Radiomics: Capturing Tumour Biology in Space and Time
Currently, there is a shift from visual interpretation of medical images, which is highly variable, to the extraction of high-dimensional meaningful data the so called Radiomic signatures that can be used in conjunction...
Normal and abnormal MRI findings after abdominal radical trachelectomy (ART) for cervical cancer
Purpose: To report MRI findings after abdominal radical trachelectomy (ART) for early-stage cervical cancer. Material and Methods: During an 8-year period, 25 women (mean age: 32 years) with biopsy-proven cervical cance...
Is Radiology a clinical specialty?:The concept of the invisible radiologist
Ιt should be stated right from the start that Radiology is a clinical specialty and the radiologist is a clinician with special training in methods of exceptional diagnostic significance and dynamically expanding range....