Latent variable modelling of risk factors associated with childhood diseases: Case study for Nigeria
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2011, Vol 1, Issue 3
Abstract
Objective: To investigate the impact of various bio-demographic and socio-economic variables on joint childhood diseases in Nigeria with flexible geoadditive probit models. Methods: Geoadditive latent variable model (LVM) was applied where the three observable disease (diarrhea, cough, fever) variables were modelled as indicators for the latent individual variable "health status" or "frailty" of a child. This modelling approach allowed us to investigate the common influence of risk factors on individual frailties of children, thereby automatically accounting for association between diseases as indicators for health status. The LVM extended to analyze the impact of risk factors and the spatial effects on the unobservable variable “health status ” of a child less than 5 years of age using the 2003 Demographic and Health Surveys (DHS) data for Nigeria. Results: The results suggest some strong underlying spatial patterns of the three ailments with a clear southeastern divide of childhood morbidities and this might be the results in the overlapping of the various risk factors. Conclusions: Comorbidity with conditions such as cough, diarrhoea and fever is common in Nigeria. However, little is known about common risk factors and geographical overlaps in these illnesses. The search for overlapping common risk factors and their spatial effects may improve our understanding of the etiology of diseases for efficient and cost-effective control and planning of the three ailments.
Prebiotic effect of Jerusalem artichoke (Helianthus tuberosus) fructans on the growth performance of Bifiobacterium bifium and Escherichia coli
Objective: To investigate and compare in vitro prebiotic effects of Jerusalem artichoke polyfructans on the survivability and activity of Bifiobacterium bifium and Escherichia coli with high performance-inulin (a high mo...
Epidemiology and prevention of animal bite and human rabies in a rural community-One health experiment
Objective: To estimate the incidence of human rabies and animal bite/exposure; to describe the post exposure prophylaxis received by animal bite/exposure cases; to assess the safety and immunogenicity of rabies vaccine (...
Effects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice
Objective: To evaluate antianxiety property of Lactuca sativa, an important and commonly used leafy vegetable known for its medicinal properties belongs to Asteraceae family. Methods: Elevated plus maze (EPM), open field...
Spatial and statistical analyses of the relations between vegetation cover and incidence of cutaneous leishmaniasis in an endemic province, northeast of Iran
Objective: To investigate the relations between the vegetation cover and occurrence of cutaneous leishmaniasis (CL) in Golestan province during 2010-2012. Methods: Data of monthly CL incidence and remote sensing normaliz...
Malarial infection among HIV patients on antiretroviral therapy (ART) and not on ART: a case study of Federal Medical Centre Makurdi, Benue State, Nigeria
Objective: Malarial infection among patients on antiretroviral therapy (ART) attending Federal Medical Centre Makurdi, Benue State was investigated between April and August 2008. Methods: A total of 1080 HIV patients wer...