LDL and Small Dense LDL in Normal Pregnancy and Post partum
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 3
Abstract
Normal pregnancy is associated with significant hyperlipidemia. Hyperlipidemias are well known as a modifiable risk factor for ischemic heart disease, which is one of the leading causes of morbidity and mortality worldwide. Traditionally LDL is referred to as 'Bad Cholesterol'. It is now established that more than LDL as a whole, it is the small dense subtype of LDL in particular which is responsible for the atherogenicity of LDL. In this study we aimed to determine whether normal pregnancy is associated with a shift in distribution of LDL subtypes, and whether a shift to a more atherogenic lipid profile is an inevitable consequence of normal pregnancy. 100 women with normal, uncomplicated pregnancy were enrolled in the study. Blood samples were collected in the middle of each trimester and 3-4 months post partum, and LDL and small dense LDL levels were estimated. Repeated Measures Anova with post hoc correction was used to compare the mean values of LDL and sdLDL among the different trimesters. P value < 0.05 was considered statistically significant. Normal pregnancy was associated with a progressive and significant rise in both LDL and sdLDL levels, peak values being attained in the third trimester. Post partum, LDL levels returned to the base line, whereas the sdLDL levels still remained significantly higher than the baseline. Normal pregnancy is associated with an increase in the levels of small dense sub fractions of LDL, which is not fully reversed by 3-4 months postpartum.
Authors and Affiliations
Dr. Basabdatta Samanta, Dr. Bharti K. Uppal
Keywords
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