Lead poisoning and cystatin-C in children
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 5
Abstract
Background Lead pollution is a global problem both in developed and developing countries. Lead poisoning is associated with decreased glomerular filtration rate (GFR) and is a risk factor for acute kidney injury (AKI). Serum cystatin-C is a more precise test of GFR than serum creatinine level, as serum cystatin-C levels rise earlier than serum creatinine, when GFR decreases. Objective To assess for a possible correlation between lead poisoning and cystatin-C levels in children. Methods We conducted a cross-sectional study in children aged 6-11 years with a history of lead poisoning from elementary schools in Talawaan District, North Minahasa Regency from July to October 2013. Cystatin-C and blood lead levels (BLL) were measured in all subjects. Spearman’s rho test was used to analyze a potential correlation between BLL and cystatin-C level. Results This study included 41 children, comprising 21 boys and 20 girls. Their median age was 8.50 (range 6.8-10.7) years. Elevated levels of cystatin-C did not exceed normal values, however, we found a positive correlation between BLL and cystatin C (r=0.419, P=0.006). Conclusion There is a positive correlation between BLL and cystatin C level in children with lead poisoning. Regular monitoring of BLL, medical intervention, and an epidemiological study to help find the sources of contamination are needed for children with lead poisoning.
Authors and Affiliations
Yuri Yuri, Praisilia Najoan, Stefanus Gunawan, Adrian Umboh
Keywords
Related Articles
- EP ID EP448561
- DOI 10.14238/pi55.5.2015.252-6
- Views 79
- Downloads 0
Intravenous paracetamol and patent ductus arteriosus closure in preterm infants
Background Indomethacin and ibuprofen are the drugs of choice for closure of patent ductus arteriosus (PDA) in preterm infants. However, intravenous preparations are of limited availability in Indonesia. Circumstantial e...
Relationship between age at menarche and exposure to sexual content in audio-visual media and other factors in Islamic junior high school girls
Background In recent decades, girls have experienced menarche at earlier ages, which may have negative effects on health. Exposure to audio-visual media and other factors may influence the age at menarche, although past...
Sitting height, sitting height/height ratio, arm span and arm span-height difference of healthy adolescents in Surakarta, Indonesia
Background Sitting height, sitting height/height ratio (SHR), arm span, and arm span-height difference (AHD) are indices to diagnose conditions of disproportion. Reference data on sitting height, SHR, arm span, and AHD f...
Diagnostic value of newborn foot length to predict gestational age
Background  Identification of gestational age, especially within 48 hours of birth, is crucial for newborns, as the earlier preterm status is detected, the earlier the child can receive optimal management. Newborn foot l...
Nutritional status and physical activity of childhood leukemia survivors
Background Acute lymphoblastic leukemia (ALL), the mostcommon malignancy of childhood, has an overall cure rate ofapproximately 80%. Long-term survivors of childhood ALL areat increased risk for obesity and physical inac...