Lipid based systems for ocular drug delivery: Effect of surface modification
Journal Title: Scholars Bulletin - Year 2017, Vol 3, Issue 8
Abstract
Abstract:Significant challenges forpharmaceutical scientists still exist despitenumerous technological advancements in the field, and the efficientoculardrug deliveryremainselusive. Exclusive and exquisite barriercharacteristics, unique physiology make the ocular milieu imperviousto xenobiotics. Precorneal residence, mucoadhesion and transmembrane permeation needs to be improved using topical non-invasive strategies across ocular surface show promise for the intraocular delivery. Viable advantages such as higher drugloading,tailored drugrelease, bio-compatibility and mucoadhesive properties can improve deliveryof lipophilic drug using colloidal nanoparticulateframeworks. Lipid based systems comprise solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Nanoparticles are better internalized in ocular epithelial tissues by endocytosis/transcytosis mechanisms and diffuse rapidly owing to their nano size. Penetration and retention characteristics of ocular small molecule therapeutics can be dramatically improved by the surface functionalization of lipid nanoparticles. This review summarizes scientific results such as articles and patents that involve the potential application of lipid nanoparticles as platform for the ocular drug delivery. Keywords: Ocular delivery, lipid based systems, surface functionalization, nanoparticles, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), transcorneal permeability
Authors and Affiliations
Thirupathi G, Ramesh B
Keywords
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