Lipid Metabolism in Neurocognitive Disorders: Current Update
Journal Title: Journal of Regenerative Biology and Medicine - Year 2021, Vol 3, Issue 4
Abstract
The physiology and the pathology of the Central Nervous System (CNS) is very complex, and only by understanding it the scientific research might develop effective treatments. Neurocognitive Disorders, extremely diffused diseases, have a multifactorial aetiology, in which lipid homeostasis plays an important role, as known. The aim of this mini-review is focus on interesting recently published researches on the topic, in order to put together some pieces of the puzzle of such an enormous physiopathology chapter. After a brief introduction, we will describe important aspects of CNS lipid metabolism, then we will examine the conclusions of recent articles relating to lipid role in neurodegeneration. The recent scientific literature has strengthened the position of some well-known “biological agents” – i.e. lipid peroxidation and apolipoprotein E4 allele –but also detailed the importance of new promising diagnostic and therapeutic targets.
Authors and Affiliations
Francesco Salis and Antonella Mandas*
Keywords
Related Articles
- EP ID EP707379
- DOI https://doi.org/10.37191/Mapsci-2582-385X-3(4)-075
- Views 76
- Downloads 0
Growth Factors and Articular Cartilage Rejuvenation: Where are We Up to with Reversing OA?
Osteoarthritis has eluded a curative/disease modifying treatment despite extensive research over the last century. This is largely due to the extremely slow metabolic turnover of articular cartilage in an essentially ava...
Front-line Healthcare Workers in COVID-19: The way from Elbow-Bump Greeting to Closing Body Bags
COVID-19 is a serious coronavirus disease that is spreading all over the world. As of the date of this publication, 2.834.134 people have been infected with COVID-19 and 197.924 deaths have been recorded in 185 countries...
Neurologic Manifestations of COVID-19 Disease in Children and Adults
SARS-CoV-2 has kept the world on tenterhooks for half a year. In this short time, millions of data and clinical findings have been collected, the amount of which astonishes even the scientific community. But the majority...
TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat
The enzymes trypsin, furin and other proprotein-convertasen, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role by the cell entry of Coronaviren (Coronaviridae)[1]. The proteases TMPRSS2 and TMPRSS11a,...
Pre-Conception Preparation in Non-developing Pregnancy taking into Account the Conjugal Role
The article presents the results of monitoring the onset of pregnancy after preconception preparation in 30 women with a burdened gynecological history with a high risk of recurrent non-developing pregnancy. Women, it wa...