Lipid Peroxidation and Thymidine Phosphorylase expression in Prostate Carcinoma
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2012, Vol 8, Issue 3
Abstract
[b]Aim[/b]: To understand the association between markers of oxidative stress and angiogenesis in relation to disease progression, clinical stage and cytological grade in patho-physiology of prostate carcinoma. [b]Patients and Methods[/b]: Case control study comprised of 50 prostate carcinoma patients along with 20 age and sex-matched healthy subjects as controls. Levels of malondialdehyde were measured to study the oxidative stress status in the study subjects. Angiogenesis was evaluated by studying the activity of Thymidine Phosphorylase/Platelet derived endothelial cell growth factor. [b]Results[/b]: The levels of markers of oxidative stress along with the activity of thymidine phosphorylase were found to be significantly higher in the study subjects in comparison to healthy controls. The results indicate oxidative stress and angiogenesis activity increase progressively with the increase in staging and progression of disease. [b]Conclusion[/b]: Oxidative stress and expression of angiogenesis activity points clearly that with the progression of oxidative stress there is a simultaneous progression of angiogenesis in relation to disease progression, clinical stage and cytological grade in the pathophysiology of prostate carcinoma.
Authors and Affiliations
R. Tandon, U. Rath, Deepti Pande, Reena Negi, Kanchan Karki, Hari Khanna
Keywords
Related Articles
- EP ID EP161214
- DOI -
- Views 115
- Downloads 0
THE IMPORTANCE OF OXIDATIVE PHOSPHORYLATION UNCOUPLING SYSTEMS FUNCTION FOR SURVIVING OF WINTER WHEAT SEEDLING SHOOTS DURING SHORT-TERM COLD STRESS
The influence of uncoupling of oxidative phosphorylation in mitochondria on surviving of winter wheat seedling during low-temperature stress was investigated. It was shown that infiltration of winter wheat seedling by ex...
The Influence of Gasotransmitters on Membrane Permeability and Activity of Tonoplast H+-ATPase Under Oxidative Stress
The investigation of the influence of gasotransmitters – a new class of signaling molecules – on the root tissues of red beet ([i]Beta vulgaris[/i] L.) was conducted. It was found, that hydrogen sulfide (H[sub]2[/sub]S)...
The Influence of Trematode Invasion on the Thermoresistance of Lymnaea stagnalis (Gastropoda, Pulmonata) Population from the Floodplain Reservoir of Angara River
The average terms (AT) of survival at 35°C in matured [i]Lymnaea stagnalis[/i] with different levels of trematode invasion have been determined. There were noninvaded individuals from a natural population of [i]L. stagna...
Antioxidative Defense Responses to lead-induced Oxidative Stress in Glycine max L. cv. Merrill grown in Different pH Gradient
Physiological and biochemical changes as well as the activities of anti-oxidative enzymes under lead (Pb[sup]2+[/sup]) phytotoxicity were investigated in 20 days old soybean (Glycine max L.) seedlings grown hydroponicall...
Cold Storage of Plant Tissue Cultures – Effect of Sucrose
Explants of normal (non-transformed) carrot ([i]Daucus carota[/i] L.) tissue, scorzonera crown gall ([i]Scorzonera hispanica[/i] L.) and carrot tissues transformed with [i]Agrobacterium tumefaciens[/i] (all cultured in v...