Lipid peroxidation, isoprostanes and vascular damage.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 0
Abstract
Increased lipid peroxidation has been identified as a key mechanism for the development of atherosclerosis and inflammatory vascular damage. Determination of plasma concentration and urinary excretion of some F(2)-isoprostanes (by immunometric assays or by mass-spectrometry), has been demonstrated to be a reliable approach to the assessment of lipid peroxidation, and therefore of oxidative stress in vivo . Several lines of evidence suggest that isoprostane generation may reflect oxidative stress in experimental and human atherosclerosis. Increased lipid peroxidation may precede the development of atherosclerosis. In fact, urinary excretion or plasma levels of an abundantly generated F(2)-isoprostane, 8-iso-PGF(2) have been found to be more elevated in subject with cardiovascular risk factors than in healthy subjects. Some isoprostanes, in particular 8-iso-PGF(2) have been demonstrated to have biological activities that may contribute to the progression of vascular damage inducing endothelial and platelet activation and being powerful vasocostrictors. Increased lipid proxidation may be implicated in the bioactivity of angiotensin II. Experimental data indicate that increased oxidative stress due to activation of NAD(P)H oxidase is an obligatory step in its pro-hypertensive and pro-atherosclerotic effects. Increased generation of F(2)-isoprostanes is observed in clinical and experimental conditions in which angiotensin II activity is increased. In conclusion, measurement of some F(2)-isoprostanes in biological liquids represents a reliable marker of oxidative stress in vivo. The potential contribution of these compounds to the pathophysiology of the vascular damage and atherosclerosis has not yet been defined.
Authors and Affiliations
Pietro Minuz, Cristiano Fava, Alessandro Lechi
Keywords
Related Articles
- EP ID EP154670
- DOI -
- Views 84
- Downloads 0
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Background: Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its ind...
Taurine modulates calcium influx under normal and ototoxic conditions in isolated cochlear spiral ganglion neurons.
The effect of taurine on calcium homeostasis of isolated cochlear spiral ganglion neurons under normal and ototoxic conditions was investigated using fluo-3 calcium imaging. Sole application of taurine (15 mM) induced an...
Non-epilepsy uses of antiepilepsy drugs.
Antiepileptic drugs (AEDs) affect various neurotransmitters (i.e. GABA, glutamate), receptors (i.e. GABAergic, glutamatergic), and ion channels (i.e. for sodium or calcium) which is responsible for their anticonvulsant a...
Dexamethasone reduces locomotor stimulation induced by dopamine agonists in mice.
The interaction between glucocorticosteroids and the dopaminergic system has attracted considerable attention in recent years since this link could be involved in certain psychopathological conditions including depressio...
Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats.
Background: Extensive previous research has suggested a role for serotonin (5-HT) in learning and memory processes, both in healthy individuals and pathological disorders including depression, autism and schizophrenia, m...