Lipid Profile in Metabolic Syndrome Associated with Diabetes, Hypertension, Chronic Kidney Disease and Apparent Health
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2022, Vol 5, Issue 10
Abstract
Background: There is dyslipidaemia in metabolic syndrome (MetS). Lipid profiles in MetS associated with different health conditions may not be obvious. This study investigated lipid profiles in MetS associated with type 2 diabetes (DM-MetS), hypertension (HBP-MetS), chronic kidney disease (CKD-MetS) and apparent health (AH-MetS). Methods: 540 patients were recruited for this study; 183 T2D, 136 HBP, 84 CKD patients and 137 AH subjects. They were outpatients and workers in the University of Nigeria Teaching Hospital Enugu. Nigeria. FPG, TC, HDL-C, TG as well as anthropometric measurements were determined using standard methods. Data analyses were done using GraphPad Prism version 2 statistical programme. MetS was diagnosed using NCEP-ATP 111 criteria Results: Study showed 135 DM, 64 HBP, 31 CKD and 52 AH subjects had MetS, (prevalence rates: 36.9 %, 14.7 %, 18.4 %, and 37.9 % respectively). Only 38% MetS subjects had hypertriglyceridaemia while 66% with hypertriglyceridaemia had MetS. Corresponding figures for low HDLC were 40, and 77%. CKD-MetS had higher mean value of TG and TC than others; (2.65 ± 0.16 mmol/l; F = 11.4; P =0.0001; 6.07±0.02mmol/l; p = 0.001). Variations in TC were observed across groups, (p =0.0001). HDL-C was highest in AH-MetS, (1.51 ±0.07 mmol/l) and differed with mean value of DM-MetS, (1.23 ± 0.04mmol/l, p=0.01) only. Following the pattern of TC, LDLC was lowest among DM-MetS, (2.75 ± 0.06 mmol/l) and highest among CKD-MetS, (3.65 ± 0.28 mmol/l, p =0.001) with variations across groups, (F = 6.35; p= 0.0004). Conclusion: Dyslipidemia profile varied with associated disorders. Presence of MetS is not a strong factor for development of lipid disorders in the study population.
Authors and Affiliations
Ogbu, Innocent S. I; Ph. D1, Ogbu Chinemerem C.; B.MLS, Ndukwe, Mbrey; MSc, Agunwah, Elizabeth; MSc, Eze, Clementina MSc , Okeke, Nduka J; FMC. Path
Keywords
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- EP ID EP710164
- DOI 10.47191/ijmra/v5-i10-42
- Views 75
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