Lipid Profile in Normotensive and Hypertensive Pregnant Women-A Randomized prospective study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Hypertension (HTN) during pregnancy is one of the leading causes of maternal and perinatal morbidity and mortality. The aim of our study was to evaluate the alteration of serum lipid profile during normotensive and hypertensive pregnancy. A cross-sectional comparative study was performed at tertiary care teaching hospital. Blood samples were collected from normal pregnant women(Group 1, n=50) & women with already diagnosed preeclampsia(Group 2, n=50) in third trimesters of pregnancy& concentration of serum triglyceride, VLDL, LDL, totalcholesterol & HDL was compared. Results: Group2 was associated with a significant rise in triglyceride (208.80±7.30 mg%vs. 109.20±1.29 mg %) compared to group1. There wasfall in mean HDL cholesterolconcentration in group2 (37.52 ± 0.74 mg % as against 38.9 mg ± 0.37mg % in group1) (P<0.05). The mean values of total cholesterol in normotensives was 169.74 ± 3.98 mg/dl and in hypertensive 235.40±6.02 mg %) (P<0.0001). Also LDL-cholesterol was significantly increased in group2 (mean 153.88±6.21mg %) and 129.94 ± 3.73 mg % in group1 (P < 0.0001). Very LDL-C was significantly increased in hypertensive pregnancies with mean 45.36 ± 1.99) mg% while in normotensives it was 22.24± 0.71 mg%. We conclude that human gestation is associated with an ‘atherogenic’ lipid profile that is further enhanced in preeclampsia and this profile may be a potential contributor to endothelial cell dysfunction. We recommend that pregnant female with serum lipid concentrations higher than normal pregnancy should be suspected to development of preeclampsia.
Authors and Affiliations
Khadke Chaitali Venkatesh, DrSiddique Abdul Mubashir
Keywords
Related Articles
- EP ID EP381274
- DOI 10.9790/0853-1708092428.
- Views 100
- Downloads 0
Total Protection in Patients With Exposed (Specific) Ressorption of Alveolar Ridges - A Challenge in The Everyday Practice – Case Reports
Abstract:Residual alveolar ridge resorption is an intraoral structural change in the alveolar bone associated with loss of natural teeth. This chronic, irreversible and cumulative process is most pronounced in the first...
Prospective Evaluation of Maternal Morbidity and Mortality in Post-Caesarean Section Patients Admitted To Post Anaesthesia Intensive Care Unit
Introduction: The pregnant woman is usually young and in good health before she becomes critically ill; hence, her prognosis will be hopefully be better if she receives timely intensive care intervention. The objective w...
The Bi-Directional Relationship between Diabetes Mellitus And Periodontal Disease A Structured Review And Contemporary Concepts
Objective: To review the relevant references and provide the updated knowledge about the relationship between diabetes and periodontal disease over last decade. Methodology used: A structured review of articles and clini...
Blunt Trauma Chest: A Study on Clinical Pattern
Background: Chest injuries constitute a continuing challenge to the trauma or general surgeon practicing in a developing country. This study reviews the pattern and management of these injuries mainly by general surgeons...
Eight Steps for Implementation of Selective Subspecialtymodule for Undergraduate Medical Students
Introduction: The undergraduate medical curricula should be planned to prepare the students for their future work which include the selection of their major specialties and the subspecialties. We described in this report...