Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 10
Abstract
Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid-lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabetic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. CT, TG and HDL-C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results: The results showed that CT (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL-C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ?7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ?7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.
Authors and Affiliations
Casimir D. Akpovi, Segbo A. G. Julien, Medehouenou T. C. Marc, Anago A. A. Eugenie, Akakpo B. Huguette, Frederic Loko
Failures in Endosseous Dental Implants- A Literature review
Endosseous dental implants have become commonly used in clinical situations. Despite many advances in materials, techniques and implant design, the potential for clinical failure is a significant concern for both dentist...
How accurate is MRI in prediction of musculoskeletal tumors -A prospective evaluation
Background: To determine the accuracy of MRI in determining the characteristics of musculoskeletal tumors, [including both skeletal (primary/secondary) and soft tissue tumors] and correlation of MRI findings with histopa...
Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin
Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid-lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profi...
A new horizon for tooth colored restorations using SR Adoro system A case report
Direct and indirect composite resins have been considered as a bench mark for esthetic restorations. Recently, researches have been carried out in the field of material sciences for advancement in the properties of this...
Cost-effectiveness of inguinal herniorrhaphy at a tertiary care hospital
Background: To determine the cost-effectiveness of elective inguinal herniorrhaphy for various repair methods, and to compare between them in the context of reoperation. Methods: Retrospective review of medical records...