Liquid Biopsies: As an Emerging Tool in Cancer Diagnosis and Monitoring Therapies in Metastasis
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1
Abstract
Despite the availability of advanced diagnosis and treatment methods, cancer is still a leading cause of morbidity. The most readily and routinely available method for cancer diagnosis is tissue biopsy. Tissue biopsies are generally based on molecular profiling of primary tumors, which can change during the metastasis stage. Therefore, it’s unable to give sufficient information about the tumor. These problems can be overcome by liquid biopsies which is considered as fast, non-invasive, and more sensitive method for cancer diagnosis. It also has applications in early diagnosis and real-time monitoring of tumor prognosis and development. This can be achieved by molecular profiling of circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, microRNA (miRNA), and tumor-educated platelets (TEPs) from biological fluids which are considered as biomarkers. The expression of these biomarkers gives an entire snapshot of both the primary and metastasis stages of cancer. It is very useful to determine different stages of cancer and to modify treatment strategies based on treatment response. Therefore, it opens up an opportunity to use liquid biopsies in the area of precision medicine. This review summarizes in-depth information on liquid biopsies, cancer metastasis, various methods in liquid biopsies, biomarkers such as CTCs, cfDNA, miRNA, exosomes, TEPs, and the role of these biomarkers in monitoring therapy.
Authors and Affiliations
Omkar Khade, Sagar Nagrekar, Vivek Parab, Asmita Choubey
Keywords
Related Articles
- EP ID EP740141
- DOI 10.54457/DR.202301007
- Views 57
- Downloads 1
Clinical Applications of Recombinant Human Granulocyte Colony-Stimulating Factor in Reproductive Medicine: Expert Consensus
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is primarily indicated for neutropenia caused by various etiologies in clinical practice. Recently, it has been shown to have some therapeutic effects and...
Significance of Liquid Biopsy Containing Circulating Tumor DNA (ctDNA) Analysis for Evaluation and Management of Metastatic Cancer
According to the GLOBOCAN 2020 data from WHO, nearly 10 million deaths took place due to cancer thus, cancer became a leading cause of death all over the world. The most common cancer are breast cancer, lung cancer, colo...
Application of Immunoenhancing Radiotherapy in Treating Unresectable Intrahepatic Cholangiocarcinoma: A Case Report
Unresectable intrahepatic cholangiocarcinoma currently lacks standard treatment methods. This report presents a case where PET/CT scans showed a subcapsular mass in the right posterior lobe of the liver measuring 6.2 cm...
Recurrent Middle Ear Cancer: Case Report
Background: Middle ear cancer is clinically uncommon, representing approximately 1.5% of ear malignancies and 0.03% to 0.06% of all cancers. Recurrent cases of middle ear cancer are particularly rare. This report discuss...
Clinical Progress of Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Concurrent chemoradiotherapy (CCRT) is the foundational standard-of-care for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Adding adjuvant chemotherapy (AC) or induction chemotherapy (IC) to CCR...