LIQUISOLID SYSTEMS - AN EMERGING STRATEGY FOR SOLUBILIZATION & DISSOLUTION RATE ENHANCEMENT OF BCS CLASS-II DRUGS
Journal Title: Int J of Pharm Rev& Res - Year 2013, Vol 3, Issue 2
Abstract
Now-a day‟s efforts are ongoing to enhance the oral bioavailability of lipophilic drugs/water insoluble drugs in order to increase their clinical efficacy. One of the most popular approaches includes Liquisolid technique, which is a new and most promising method that can change the solubility of more insoluble drugs. Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. Formulation and manufacture of liquisolid tablets is quite simple method according to new mathematical model described by Spireas et al. According to this concept, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable nonvolatile solvents have been converted into free-flowing and readily compressible powders by a simple admixture with selected powder excipients, which in turn acts as a self-emulsifying system in-vivo. Liquisolid compacts enhances the oral bioavailability enabling reduction in dose, shows more consistent drug absorption through temporal profiles, Selective targeting of drug(s) toward specific absorption window in GIT and protection of drug(s) from the hostile environment in gut.
Authors and Affiliations
CH. Pradeep Kumar , P. Venugopalaiah , CH. Praveen Kumar , K. Gnanaprakash , M. Gobinath
Keywords
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