Liver function in patients with liver diseases: A CT based study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic diagnosis was performed.100 patients with evidence of abnormal liver function (LFT) test were tested for correlation between the laboratory tests and CT imaging results. The study was conducted at Antalia Hospital during the period extended from 2014-2017. Total Bilirubin, Direct Bilirubin, Alkaline phosphatase(ALP), Aspartate amino transferase(AST), Alanine amino transferase(ALT), Albumin, Globulin, Total protein, and prothrombin time have been evaluated and were clearly correlated with the CT imaging results. Cholangiocarcinoma was correlated significantly with AST values at p= 0.038. Hepato cellular carcinoma (HCC) was correlated significantly with total bilirubin and with direct bilirubin at p=0.000 .liver metastases increased albumin level and is correlated significantly at p=0.030, while the prothrombin time is increased significantly with the presence of liver cirrhosis at p= 0.007.In the presence of Klatskin tumor the increasing of globulin was correlated significantly at p=0.003 and with total protein at p= 0.001 and albumin at p= 0.030. Results showed that there are no significant relation between the presence of the Hemangioma, Focal Nodular Hyperplasia and simple cyst with the total bilirubin, direct bilirubin, ALP, AST, ALT, Albumin, Globulin, Total protein, and prothrombin time Many lesions can be present and diagnosed by imaging but not affected the LFT parameters on the other hand the elevation of the laboratory tests may be caused by many different causes as they were produced from many sources. On the other hand Laboratory liver tests can help to explain the alteration of markers which reflect the liver disease including (HCC), Cholangio carcinoma, Klatskin tumor, metastases and cirrhosis .The assessment of enzyme alteration, associated with CT examination in the diagnosis of the disease is important. And a single laboratory liver test is of little value in screening for liver disease as many serious liver diseases may be associated with normal levels and abnormal levels might be found in asymptomatic healthy individuals
Authors and Affiliations
Nihad Fatah Elrahman Osman Ibrahim, Caroline Edward Ayad
Keywords
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- EP ID EP377211
- DOI 10.9790/0853-1707031114.
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