Liver function test and its alteration in female genital and gonadal carcinoma patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Introduction: Gynecological cancer is one of the most common leading cancer in worldwide as well as India. Liver function tests are helpful to evaluate patients with hepatic dysfunction. These biomarkers may be used to identify the presence of liver disease during the follow-up period. The aim of the study was to evaluate any association between liver function parameters and pattern of liver dysfunction in metastasis of female genital and gonadal cancer patients. Materials and Methods: In this study 100 female genital and gonadal cancer patients and 100 women with benign genital and gonadal diseases who attended at Out Patient Door (OPD) of IPGME&R and SSKM Hospital, Kolkata, India during the period from June, 2016 to June, 2017 were included. Liver function test (LFT) was measured by semi auto analyzer by ERBA Chem - 5 Plus V2 by TRANSASIA using spectrophotometry principle. Statistical analysis was done by SPSS 20.0.1 software. Results and Analysis: Statistical significant association was found between ALP, albumin, globulin and ratio with disease status (Table-1). The significant difference was in ALP, albumin and globulin for the cancer patients (Table-2). As per cancer stage, t-test showed that ALT of the advance stage (stage-0, I, II) of cancer patients was significantly higher than that of early stage (stage-III, IV) (t98-2.29; p=0.024) and ALP of the advance stage of cancer patients was significantly higher than that of early stage (t98-2.33; p=0.022). Discussion and Conclusion: Estimation of ALP levels in serum was less sensitive than imaging procedure, but it may be valuable for screening and early detection for metastases in female genital and gonadal cancer patients.
Authors and Affiliations
Dr. Debarshi Jana, Dr. Himadri Nayek, Dr. Samindranath Basak, Prof. (Dr) Subash Chandra Biswas
Keywords
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- EP ID EP377314
- DOI 10.9790/0853-1707055862.
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