Long term cognitive outcome in herpes simplex encephalitis
Journal Title: Indian Journal of Neurosciences - Year 2018, Vol 4, Issue 1
Abstract
Aims Herpes Simplex Encephalitis HSE is a leading cause of acquired cognitive disability We aimed to describe cognitive sequelae of HSE in relation to clinical variables during hospitalizationMethods Consecutive cases of encephalitis with a discharge diagnosis of HSE from January 2010 to December2016 were reviewed to collect the clinical details GlasgowOutcomeScore GOS BarthelIndex BI SeizureScore EngelScore ES at the time of discharge first followup and final followup were noted A detailed neuropsychological evaluation was done at last followup in survivors and these scores were compared to clinical variables during hospitalization c2 test Fisherrsquos exact test and ANOVA were used for analysisResults There were 30 patients 11males at a median age of 315years Cerebrospinalfluid was abnormal in 828 electroencephalogram in 967 and Magnetic Resonance Imaging MRI in 80 patients All were treated with acyclovir and 80 had intensivecareunit stay Mortality was 267 and it correlated with glasgow coma score lt8 status epilepticus and Periodic Lateralized Epileptiform Discharges PLEDs in electroencephalogram At the first followup of 84plusmn52 weeks and final followup of 366plusmn265 months survivors had a good functional recovery with GOS45 and BI90100 At final followup median ES was one ES was not correlated with seizures statusepilepticus electroencephalogram or MRI features At final followup 518278 had significant neuropsychological verified cognitive abnormalities and those with longest followup had least abnormalities Neuropsychological profile didnrsquot correlate with any clinical variables other than the association of poor attention score and orbitofrontal signal changes in MRIConclusions Acyclovir treated HSE has a mortality of 267 but survivors have good functionalseizure outcome Significant cognitive problems occur in a third but not related to any clinical variablesKeywords Encephalitis Herpes Outcome Cognitive outcome Neuropsychology
Authors and Affiliations
Firosh Khan, Fazal Ghafoor, Abdulkhader Shehna
Keywords
Related Articles
- EP ID EP490469
- DOI -
- Views 82
- Downloads 0
Posterior cervical discectomy: An optimally invasive approach to laterally prolapsed cervical disc
Aim: Posterior cervical discectomy is one of the surgical techniques for management of laterally prolapsed cervical disc causing cervical radiculopathy. This method has remained under-utilized in comparison to the classi...
Role of Serum CPK and Serum Magnesium Level as a Predictor of Impending Intermediate Syndrome in Patients of OP Poisoning.
Introduction: Organophosphorus poisoning is one of the most common and deadliest poisoning especially in country like India. The intermediate syndrome occurred after the acute cholinergic syndrome but before organophosph...
Burden, coping and functionality of the patients with neurological disability availing treatment at neuro rehabilitation ward
Neurological conditions are the one where Rehabilitation place a major role because of its magnitude, manifestation and long term impact on the person and his/her family as whole. Neurological conditions pose great threa...
Intramedullary epidermoid cyst of spinal cord: Experience of 24 Cases at a Tertiary Care Institute
Introduction: Epidermoid cyst is the sequel of developmental aberration often intriguing the neurosurgeons. Intramedullary epidermoid cysts are rare entities with delay and variability in the clinical presentation. The a...
A study on the prevalence of internet addiction and its association with psychopathology in Indian adolescents
Introduction: Internet addiction is a major problem of the world and not merely restricted to India. Amidst abnormal and excessive internet use, concern is the implication it may have on the vulnerable brain of children....