Low Dose Dexamethasone Reduces Spinal Buprenorphine Associated Nausea and Vomiting
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 1
Abstract
Intrathecal Buprenorphine is an adjuvant to spinal anaesthesia offers the advantage of providing good analgesia, but is associated postoperative nausea and vomiting. Dexamethasone is a potent steroid and has good antiemetic effect. The aim of this randomized controlled trial was to compare the antiemetic efficacy of dexamethasone 4 and 8mg. Methods: 180 patients of either sex undergoing elective lower extremities and infra umbilical surgeries were included in the study. The patients in group D0, D4 and D8 received 5ml normal saline, 4 mg and 8mg dexamethasone respectively before spinal anaesthesia. Spinal anaesthesia was established with a single bolus of 0.5% hyperbaric bupivacaine 15 mg and buprenorphine 60mcg. The primary end point of this study was the total nausea and vomiting rate for 8 hours post spinal anaesthesia. The secondary end points were the incidence of nausea, vomiting and the occurrence of adverse events like pruritis. Statistical Analysis: The incidence of nausea, vomiting and pruritus was analyzed using a series of 3×2 c2 tests. Results: Demographic profile was similar between the groups. The incidence of nausea was 16% in group D0 and was 5% in the groupD4 and D8. The incidence of vomiting was 5%, 3.3%and 1.7% in the D0, D4 and D8 groups respectively. The incidence of nausea and vomiting was not very different in the D4 and D8 groups. Conclusions: Both doses of prophylactic dexamethasone 4/8 mg significantly reduces the nausea and vomiting associated with intrathecal Buprenorphine. A dose of 4mg of dexamethasone is as efficacious as 8mg.
Authors and Affiliations
Purushothaman Athul M
Keywords
Related Articles
- EP ID EP524550
- DOI 10.21088/ijaa.2349.8471.5118.6
- Views 99
- Downloads 0
Comparison of Paravertebral Block and Interpleural Block in Patients Undergoing Breast Surgery Under General Anaesthesia
Background and Aims: Paravertebral and interpleural blocks are indicated for providing intraoperative and postoperative analgesia in unilateral surgeries of the chest and abdomen. The aim of this study was to evaluate th...
Comparison of 6% Hydroxyl Ethyl Starch and Ringer’s Lactate for Preloading in Caesarean Section under Spinal Anaesthesia
Background: Therefore the present study was undertaken to study on comparison of 6% hydroxyl ethyl starch with Ringer’s Lactate for preloading in caesarean section under spinal anaesthesia. Objectives: To study the effec...
Comparative Study of Preoperative Biateral Infraorbital Nerve Block with Peri Inscisional Infiltration for Post Operative Pain Relief in Cleft Lip Surgery
Background: Post operative pain relief is an integral part of anaesthetic management especially when it comes to pediatric patients where it requires special attention. Aim: to study two different techniques – peri insci...
Effect of Dexmedetomidine on Emergence Characteristics in Children Undergoing Adenotonsillectomy Using Sevoflurane Anaesthesia
Background: Sevoflurane, a widely used volatile anaesthetic in children is associated with an increased risk of emergence agitation. Agitation can lead to increased bleeding from the operative sites, pulling out drains o...
Role of Intravenous Paracetamol for Peri-Operative Pain Management in Head and Neck Cancer Surgeries
Background: Inadequately controlled postoperative pain causes discomfort, increased use of medications, slower recovery, longer hospital stay and increased risk of pulmonary complications [5]. Postoperative analgesia wit...