Low Grade Gliomas: Current Concepts and Controversies
Journal Title: Nepal Journal of Neuroscience - Year 2006, Vol 3, Issue 1
Abstract
Low grade gliomas (LGGs) are a heterogeneous group of relatively slow-growing primary tumors and account for 30% to 40% of all gliomas. Under the recent World Health Organization classification of primary intracranial tumors, low grade gliomas would encompass grade I and grade II neuro-epithelial tumors. The more common grade I tumors are pilocytic astrocytoma, dysembryoblastic neuro-epithelial tumors (DNET), pleomorphic xantho-astrocytoma (PXA), neurocytoma, and ganglioglioma. The more common grade II tumors include astrocytoma, oligodendroglioma, and mixed oligoastrocytoma. With the increasing use of CT and MRI scans for investigation of “vague” neurological symptoms, an increasing number of low grade gliomas are being found incidentally. The management of low grade glioma is one of the most controversial areas in clinical neuro-oncology. More precise definition of tumor entities, including also specific molecular markers, is necessary to identify patients in need of a more aggres-sive treatment strategy. Management options in low grade glioma include control of seizures, watch and wait, surgery, radiotherapy and chemotherapy. In this paper we review the current concepts and controversies in the management of low grade gliomas.
Authors and Affiliations
Amit Agrawal, MCh
Keywords
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