LUNG CANCER STEM CELLS:AN UPDATE
Journal Title: Era's Journal of Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Lung cancer is regarded as one of the most common cancers in the world with a worldwide occurrence of approximately 1.8 million cases and an estimated mortality of 1.6 million in 2012 alone.1 In the United States, there are approximately 2,25,000 new cases of lung cancer with over 1,60,000 deaths annually. Lung cancer is a very serious problem of the Indian subcontinent, especially in the lower socioeconomic subgroups. In India lung carcinoma is the 5th most common tumor and 2nd most common tumor in the males as per the ICMR [Indian Council Of Medical Research] registry of 2002.It accounts for 6.9% of new cancer cases detected each year.3 The importance of study of stem cells and cancer stem cells lays in CSC acting as prognostic and therapeutic markers. It is a known fact that there are innate stem cells present in the lining of the bronchial epithelium, at the carina and alveolar lining which help in regeneration of lungs post injury , however there are present similar cells which post driver mutations are christened CSC and help in cancer survival, growth and chemo resistance. CSC also known as “cancer stem-like cells” (CSLCs), or “tumor-initiating cells” (TICs) are heterogeneous cell population comprising of a small subpopulation of cancer cells with the property of self-renewal and differentiation. CSCs are thought to be responsible for cancer initiation, progression, metastasis, recurrence, and drug resistance.Important CSC under study in lung are, CD 133, ALDH 1, CD 44,ABCG2 etc.
Authors and Affiliations
A. N Srivastava, Neema Tiwari, Shailendra Yadav, Surya kant
Keywords
Related Articles
- EP ID EP282386
- DOI 10.24041/ejmr2017.4
- Views 158
- Downloads 0
PREVALENCE OF TINEA CAPITIS IN A TERTIARY CARE HOSPITAL, NORTH INDIA
Fungal infections are common in humans worldwide. Hot and humid weather conditions in the tropical countries like India make humans very susceptible to fungal infections. Tinea capitis (TC) is the superficial fungal infe...
DIABETIC MACULAR EDEMA IN ASSOCIATION WITH DIABETIC RETINOPATHY IN PATIENTS OF TYPE 2 DIABETES MELLITUS
Diabetic Retinopathy is an important cause of blindness with diabetic macular edema(DME) affecting 15% of patients 15yrs after diagnosis. The prevalence of diabetes mellitus(DM) is expected to approximately double global...
THE STUDY OF NUTRIENT FORAMEN OF BONES OF ARM AND FOREARM IN ADULTS
The variation in presence of number of nutrient foramen is important in long bones as nutrient foramen gives passage for entrance of nutrient arteries in to the bone. The present study was conducted on total 114 dry huma...
TAKAYASU ARTERITIS : A RARE PULSELESS DISEASE
Takayasu arteritis was formerly known as a “pulseless” disease and is a chronic idiopathic vasculitis affecting the large vessels in the body most commonly the aorta. Takayasu arteritis is a rare condition and its acute...
THE MORPHOLOGICALAND MORPHOMETRIC STUDY OF SUPRASCAPULAR NOTCH AND ITS VARIATIONS
The Suprascapular notch is situated in the lateral part of the superior border of the scapula, just adjacent to the base of Coracoid process. The notch is bridged by the superior transverse scapular ligament (STSL) which...