Macitentan therapy for bosentan hepatic intolerance in Eisenmenger’s syndrome patient. (RCD code: II-1A.4d)
Journal Title: Journal of Rare Cardiovascular Diseases - Year 2016, Vol 2, Issue 8
Abstract
Pulmonary arterial hypertension associated with congenital heart disease is included in clinical group 1 pulmonary arterial hypertension. Eisenmenger’s syndrome develops over time as a result of large intra- and extra-cardiac arterial and venous blood communication. The pulmonary vascular resistance (PVR) increases and thus the systemic-to pulmonary blood flow reverses direction, producing a pulmonary-to-systemic shunt (Eisenmenger’s syndrome). Bosentan, an oral endothelin receptor antagonist A and B, is recommended in monotherapy and drug combination therapy in this group of patients. Liver toxic reactions occur in about 10% of treated patients but severe hepatotoxicity is rare. We present a clinical case of a patient with Eisenmenger’s syndrome due to large ventricular septal defect. The patient was for many years successfully treated with bosentan and subsequently developed drug-induced hepatitis. JRCD 2016; 2 (8): 259–262
Authors and Affiliations
Marta Nowakowska, Agnieszka Mossakowska, Lukasz Chrzanowski, Michał Simiera, Jarosław Kasprzak
Keywords
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- EP ID EP248027
- DOI 10.20418/jrcd.vol2no8.254
- Views 114
- Downloads 0
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