Macro rheological and micro rheological parameters: Can they be used as early indicators of macro vascular and micro vascular complications in diabetes mellitus type II
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 6
Abstract
Introduction & Background: Diabetes mellitus is one of the most common and complex metabolic disorders and it is characterized by disordered metabolism and abnormally high blood sugar (hyperglycaemia) resulting from either low insulin level or low insulin resistance in many body cells. It is a chronic illness characterized by macro vascular and micro vascular complications. Aim: The aim of the study is to find out the effects and changes of various haemorrheological parameters in diabetes and the relationship between these parameters and HbA1c in Type II DM. Materials and Methods: This was a retrospective study conducted on patients with Type II Diabetes Mellitus. The data of these diabetic patients were obtained from our Diabetic and Obesity Research Department, at Sree Balaji Medical College and Hospital, Chennai, Tamil, Nadu. For these included subjects, the various haematological and biochemical values were collected from our Laboratory Database using the Laboratory Information System. All the parameters studied under a complete hemogram namely haemoglobin, RBC count, Packed Cell Volume, Red cell distribution Width, Total WBC count, Differential count, Platelet count, Platelet indices were compared with the HbA1C values in this study subjects. The correlation graphs were designed using SPSS software version ----. Results: It was observed that there was a significant correlation with Platelet Distribution Width and Mean Platelet Volume with the levels of fasting blood glucose and HbA1c. None of the other parameters showed significant correlation. Conclusion: Hence, to conclude, platelet indices could be used as a haemorheological early marker for advancement in the pathology of diabetes and hence its macro vascular complications like atherosclerosis and also micro vascular complications like coronary artery disease.
Authors and Affiliations
Dr. Hamsini C, Dr. Priavadhana Rajan Prasaad, Dr. Karkuzhali Ponnuswamy
Keywords
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