MACROPHAGES AS A KEY FACTOR IN THE PROCESS OF TUMOUR FROM THE INITIATION TO THE THERAPY OF CANCER.
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 5
Abstract
The tumor environment is a complex ecological system made up of cells and serves as support to the tumor cells from their implantation to the state of malignancy. Among all the cells of immunity (innate and adaptive) macrophages are those most present on the site of the tumor, playing a predominant role in all stages where they intensively promote the different aspects of tumor initiation, growth and development. Macrophages are composed of two subpopulations M1 (anti-tumor, responsible of the inflammation response and pathogen clearance) and M2 (pro-tumor and anti-inflammatory activities) both depending of diverse external factors. Clinical studies and experimental models have shown that tumor associated macrophages (TAMs) are more related to the M2, giving a poor clinical prognostic by promoting the growth of the tumor and assessing a favorable microenvironment to the malignancy. Thus, this ability to promote tumor proliferation makes these TAMs a key tool targets for curative cancer solutions via translational approaches, but more research need to be done to ensure a better prognosis.
Authors and Affiliations
Prof. Yong Yang
Keywords
Related Articles
- EP ID EP617632
- DOI -
- Views 177
- Downloads 0
QUALITY VERIFICATION OF SIX MEDICINES IN WHOLES AND HALVES TABLETS, RE-PACKAGED IN INDIVIDUAL PLASTIC COMPARTMENTS DURING SIXTY DAYS
Plastic boxes with individual compartments are often used to improve medication compliance and only a few studies have been done on the stability of the tablet halves after placing them on these devices. In this investig...
DOPAMINE IN SCHIZOPHRENIA IT’S TREATMENT WITH NEWER ATYPICAL ANTIPSYCHOTICS: AN OVERVIEW
Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels and behaves. People with schizophrenia may seem like they have lost touch with reality. Although schizophrenia is not as commo...
CURRENT DEVELOPMENTS REGARDING GHB AND GBL INCIDENTS, TREATMENT AND DETECTION: A QUALITATIVE REVIEW
In this qualitative review we address the neuropharmacological properties of gamma-hydroxybutyric acid (GHB) and its precursor gamma-butyrolactone (GBL), which explain why these drugs are highly addictive, and cause seri...
THE MEDICAL MYCOLOGY AND THE LEGACY OF ANTONIO GONZALEZ OCHOA
This work presents an approach of the scientific work of Dr. Antonio González-Ochoa, prominent Mexican mycologist and dermatologist. His research had a deep transcendence in the national and international medical mycolog...
A REVIEW ARTICLE ON PRONIOSOMES
In recent times, no single drug delivery system fulfills all the criteria, but attempts have been made through novel approaches. Many novel approaches emerged covering various routes of administration, to achieve either...