Magnitude of Inducible Clindamycin Resistance in Clinical Isolates of Staphylocccus aureus in a Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Staphylococcus aureus is associated with a variety of infections ranging from skin infections to life threatening illness. Therapeutic failure to Clindamycin has been reported due to mechanisms which confer resistance constitutively, or by the presence of low level inducers which can lead to therapeutic failure. Therefore, this study was undertaken to identify the strains that have the potential to become resistant during therapy. Inducible Clindamycin resistance was tested by the Clindamycin disc induction test (D test) as per the CLSI recommendations. The study showed 53.02% MRSA isolates and 22.73% inducible Clindamycin resistant isolates among them as compared to 10.25 % in MSSA isolates. We concluded that routine screening for inducible resistance to Clindamycin must be performed so that the drug is used effectively and for maximum clinical utility.
Authors and Affiliations
Dr. Sadhana Joshi, Dr. Ramesh Mishra, Dr. Nita Pal, Dr. Rakesh kumar Maheshwari
Keywords
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