Malformations of cortical development and epilepsy: Clinical, EEG and neuroimaging findings in children
Journal Title: Dicle Tıp Dergisi - Year 2014, Vol 41, Issue 3
Abstract
Objective: of this study was to evaluate the relationship between clinical and treatment features of malformations of cortical development (MCD) in children Methods: We performed a comprehensive analysis of EEG features, treatment, clinical and neuroimaging findings in 40 consecutive patients. Results: We are reporting a series of 40 cases with cortical malformation and epilepsy. The ages of our patients at the time of evaluation varied between 4 month and 17 years with a mean of 5.4 years. 57.5% were male and 12.2% of the cases had a family history of epilepsy or other neurological disease, and 15% had gestational or a perinatal insult. Delayed motor and mental milestones were observed in 70%. All type of seizures were reported, but generalized seizures was the most common (18/40, 45%). Patients were on either a single antiepiletic drug (13/40, 32.5 %) or multiple drugs (27/40, 67.5%). Complete seizure control was achieved in 19/40 patients (45.5%), partial control in 7/40 (17.5%) patients, and no control in 14/40 (35%). Lissencephaly, schizencephaly and polymicrogyria were seen as the most common neuroimaging findings in our study. Epilepsy was controlled in most patients with schizencepahly and polymicrogyria. In contrast, seizures were not controlled in patients with lissencephaly and emimegalencephaly. Conclusion:Malformations of cortical development are responsible for a wide spectrum of clinical manifestations that include develomental delay, mental retardation and medically refractory epilepsy. Key words: Epilepsy, malformations of cortical development, MRI, EEG
Authors and Affiliations
Ayşe Kartal, Kürşad Aydın
Keywords
Related Articles
- EP ID EP110808
- DOI 10.5798/diclemedj.0921.2014.03.0454
- Views 97
- Downloads 0
The evaluation of efficacy of subtenon triamcinolone injection combined with focal laser photocoagulation in diabetic macular edema
Objectives: The aim of this study was to investigate efficacy and safety of subtenon triamcinolone (ST) in combination with focal laser photocoagulation in diabetic macular edema (DME). Materials and methods: Medical...
The standard of knowledge for cesarean section in women who applied to family medicine: Two centered cross-sectional study
Purpose: We aimed to examine, mothers' level of knowledge about complications of cesarean section and the factors that influence preference for cesarean section in this study Methods: The universe of the study consiste...
Simultaneous bilateral tibal tubercle avulsion: A rare fracture
Tibial tuberosity avulsion is a rare fracture in adolescence. Due to the shear forces on the immature epiphysis. Thirteen years old girl was admitted to the emergency department with knee pain and tenderness in bot...
Lomber ponksiyon sonrası paraparezi ile belirti veren Hemofili A olgusu
Hemofili A da büyük eklem içi kanamalar sık görülmesinin yanısıra, nadiren spinal eklemlerde de oluşabilir. Travmatik ya da spontan hematomların yanısıra kordun baskılanması, epidural tümor ve infeksiyonlar, myeloskleroz...
Superior mesenteric artery syndrome causing growth retardation
Superior mesenteric artery syndrome is a rare and lifethreatening clinical condition caused by the compression of the third portion of the duodenum between the aorta and the superior mesenteric artery’s proximal part....