Malondialdehyde and Pentosidine in Young Type 1 Diabetic Patients
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 4
Abstract
Objective: To investigate whether advanced glycosylation end products (AGE) and oxidative stress are augmented in young patients with type 1 diabetes at early clinical stages of the disease. Patients and Methods: The study included 50 patients with type 1 diabetes among those attending the endocrine clinic in National Research Centre and 30 healthy volunteers in the control group. Serum glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides, serum creatinine concentrations, glycosylated hemoglobin (HbA1c), urinary albumin/ creatinine ratio, malondialdehyde and pentosidine were assessed. Results: No significant difference was found between age of patients (12.0 ± 3.2 ) and controls (11.0 ± 1.2), P > 0.05. Blood glucose, HbA1c, urinary albumin / creatinine ratio, pentosidine and malondialdehyde were significantly higher in diabetic patients than controls. Pentosidine and malondialdehyde had a significant positive correlation with blood glucose, HbA1c and urinary albumin/creatinine ratio. Conclusion: The present study indicates that accumulation of AGEs, whose formation is closely linked to oxidative stress, and resultant endothelial dysfunction may start early in the course of type 1 diabetes. This means that the risk of vascular complications may be present at an early age and that the best possible glycemic control should be emphasized from the diagnosis of diabetes.
Authors and Affiliations
Soha M. Abd El Dayem| Pediatrics Department, National Research Centre, Medical Physiology, El Tahrir St., Dokki Cairo, Cairo 12622, Egypt, Ehsan A. Badawy El Sheikh| Medical Biochemistry Department, Chemistry, Cairo, Egypt, Sadek Saied Abdou| Medical Biochemistry Department, Chemistry, Cairo, Egypt, Mervat Harvi Agaibyi| Medical Biochemistry Department, Chemistry, Cairo, Egypt, Marwa Mahmoud| Medical Biochemistry Department, Chemistry, Cairo, Egypt
Keywords
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- EP ID EP8892
- DOI 10.3889/MJMS.1857-5773.2012.0266
- Views 337
- Downloads 17
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