Mammary Analogue Secretory Carcinoma of Salivary Gland – A Diagnostic Dilemma
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 12
Abstract
Mammary Analogue Secretory Carcinoma (MASC) of salivary gland is a recently described entity with unique morphologic, clinical and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast. Before their initial description, these salivary gland tumours were generally diagnosed as acinic cell carcinoma or adenocarcinoma. We present a case of 32-year-old, male presenting with painless swelling over left cheek which was gradually increasing in size. The histopathological examination of the lesion was done and two possible differential diagnosis were acinic cell carcinoma (papillary cystic variant) and MASC of the parotid gland. Immunohistochemistry was performed which demonstrated combined positivity for S-100, mammglobin, CK-7 and DOG-1 negativity which confirmed the diagnosis of MASC of parotid.
Authors and Affiliations
Chetan S Chaudhari, Shruti Chandrakar, Ganesh R Kshirsagar, Prashant V Kumavat, Nitin M Gadgil
Keywords
Related Articles
- EP ID EP367451
- DOI 10.7860/JCDR/2017/32246.10961
- Views 58
- Downloads 0
Functional Results of Communited Intraarticular Distal Humerus Fractures Treated with Bicolumnar Plating
Introduction: Communited intra-articular distal humerus fractures are commonly encountered in orthopaedic practice and they are present with unique difficulties for internal fixation. This problem is especially worse in...
Paranasal Sinus Carcinoma Dissimulating as Alveolar Osteitis
Images in Medicine
Prevalence of Urinary Incontinence among Females with Vaginal Delivery, Lower Segmental Cesarean Section, Diabetic and Hypothyroidism and Its Impact on Quality of Life
Introduction: Urinary incontinence is defined as involuntary loss of urine that represents both hygienic and social problem to the individual. Prevalence of urinary incontinence in women is nearly 30 to 40% in middle age...
Prognostic Significance of First Week NT-ProBNP Levels in Heart Failure
ABSTRACT Introduction: Clinical history, signs and symptoms along with non-invasive imaging help in diagnosis and management of Heart Failure (HF). Limited data exists in evaluating the role of cardiac biomarkers in diag...
Knowledge and Practice of Small Family Norm among Married Women in an Urban Area of Tamil Nadu
ABSTRACT Introduction: India is the second most populous country in the world having a rapidly growing population. To strike a balance between population growth and resource usage, strategies like family planning came in...