Mandibular Brown Tumor Linked to Tertiary Hyperparathyroidism: A Case Report
Journal Title: Journal of Dental Health and Oral Research - Year 2025, Vol 6, Issue 1
Abstract
Introduction: Brown Tumors (BT) are rare, non-neoplastic, osteolytic lesions associated with Hyperparathyroidism (HPT). BTs are rare in the craniofacial region and diagnosis is uncommon in children. Case report: A nine-year-old female presented with significant cortical expansion of the anterior, right mandible with an intact mucosal surface and mobility of permanent incisors (#23-26). The medical history included end-stage renal disease secondary to hypoplastic kidneys, severe malnutrition, rickets disease and tertiary HPT (2494 pg/mL). Blood urea nitrogen (68 mg/dL), calcium (12.3 mg/dL), and creatinine (4.1 mg/dL) values were elevated. The patient received regular hemodialysis along with vitamin D supplements and calcimimetics. The panoramic radiograph revealed a diffuse, ground-glass appearance of bone, consistent with renal osteodystrophy. Computed tomography imaging exhibited a well-circumscribed, osteolytic lesion with cortical thinning of the right mandible in the parasymphyseal region (11×13×12 mm). Histopathologic examination demonstrated a giant cell lesion, consistent with BT. Conclusion: Management of BT ranges from conservative intralesional steroid injection to recontouring or excision. In this case, ongoing management aims to stabilize renal insufficiency and hyperparathyroidism, which is essential for achieving partial or complete resolution of the BT.
Authors and Affiliations
Shahbaz Katebzadeh1, Catherine Flaitz2, Donald Hull3, Anne Wilson4, Chaitanya Puranik5
Keywords
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- EP ID EP755260
- DOI https://doi.org/10.46889/JDHOR.2025.6101
- Views 18
- Downloads 0
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