Manganese-Enhanced MRI: An Exceptional Tool in Translational Neuroimaging
Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4
Abstract
The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.
Authors and Affiliations
Afonso C. Silva, Nicholas A. Bock
Keywords
Related Articles
- EP ID EP683283
- DOI 10.1093/schbul/sbn056
- Views 102
- Downloads 0
Comparing Genes and Phenomenology in the Major Psychoses: Schizophrenia and Bipolar 1 Disorder
Twin studies show that the concordance rate for schizophrenia is higher in monozygotic twins (47%–56%) than in dizygotic twins (12%–16%), suggesting a strong heritability component for the illness. Some s...
An Investigation of the Relationship Between Activation of a Social Cognitive Neural Network and Social Functioning
Previous work examining the neurobiological substrates of social cognition in healthy individuals has reported modulation of a social cognitive network such that increased activation of the amygdala, fusiform gyrus, and...
Implications of Clinical Trial Design on Sample Size Requirements
The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison group...
Measuring Specific, Rather than Generalized, Cognitive Deficits and Maximizing Between-Group Effect Size in Studies of Cognition and Cognitive Change
While cognitive impairment in schizophrenia is easy to demonstrate, it has been much more difficult to measure a specific cognitive process unconfounded by the influence of other cognitive processes and noncognitive fact...
Making Progress in Schizophrenia Research