Mast-cell rich perivascular dermatitis accompanying the ulcerative lesions resulting from infection of Staphylococcus aureus in C57BL/6 mice
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 2
Abstract
The purpose of this study was to investigate the health status of mice and rats in our laboratory animal facilities. In addition, the author encountered sporadic cases of the ulcerative skin lesions, and then the dermatological lesions were evaluated for their macroscopic and microscopic changes. Health monitoring of specific pathogen free (SPF) and conventional animals (mice and rats) was accomplished in our laboratory center for years 2008 through 2011. Our results of rodent health monitoring programs showed that incidence of SPF rodents by Staphylococcus aureus (S. aureus) was higher than that of conventional rodents (p<0.01). During the health monitoring program, severe ulcerative dermatitis was found in mice of the C57BL/6 strain. The lesions were characterized by full-thickness epidermal coagulation necrosis with extensive ulceration and marked inflammatory cell infiltration in the dermis. Infiltration of dermal mast cells apparently increased in the skin lesions. This study revealed that simplification of the intestinal normal flora caused colonization infection by S. aureus in SPF rodents. C57BL/6 mice were predisposed to severe ulcerative dermatitis infected with S. aureus. The ulcerative lesions suggested that mast cells should be critically involved in initiating and modulating optimal host responses to bacteria by either inflammatory or anti-inflammatory effects, depending on the course of the host reaction induced by the pathogen (S. aureus). This skin disease was diagnosed with mast-cell rich perivascular dermatitis accompanying the ulcerative lesions.
Authors and Affiliations
Tohru Kimura
Keywords
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