MATERNAL AND PERINATAL FACTORS AFFECTING CORD BLOOD THYROID STIMULATING HORMONE LEVEL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Incidence of Congenital Hypothyroidism in India is relatively high when compared to that of other parts of the world. The fact that only 5 - 10% can be diagnosed clinically signifies the role of screening program for early diagnosis and early initiation of therapy to treat this preventable cause of intellectual disability. Cord blood TSH (CB TSH) estimation has high sensitivity, but various maternal and perinatal factors affect the CB TSH levels, which may interfere with the interpretation. This study was done to find out the various maternal and perinatal factors affecting CB TSH level. MATERIALS AND METHODS A hospital-based cross-sectional study was conducted in the Department of Neonatology, Govt. Medical College, Ernakulam over a period of one year from February 2016 to January 2017. We enrolled 127 live neonates selected by systematic random sampling method. Cord blood TSH level was estimated and the results were statistically analysed with respect to various maternal and perinatal factors. RESULTS Mean CB TSH in the study population was 9.713 ± 7.286. The risk factors for a significantly high CB TSH level were low Apgar at 1 minute, Preterm babies and Primigravida mothers (p < 0.05). A significantly low CB TSH was noted in preterm neonates who received antenatal steroids (p < 0.05). The other factors like gestational diabetes, gestational hypertension, gender of the baby, birth weight and meconium stained liquor were found to have no significant relationship with the CB TSH level. CONCLUSION Mainly low Apgar at 1 min which is an indicator of foetal distress/ perinatal asphyxia, prematurity and parity contributed to the significant elevation of CB TSH level. Antenatal steroids can significantly blunt the TSH surge. Due consideration should be given to these factors while interpreting CB TSH levels.
Authors and Affiliations
Vinoth Kumar S. P, Peter Pathrose Vazhayil, Indhiradevi Balusamy
Keywords
Related Articles
- EP ID EP418224
- DOI 10.14260/jemds/2018/543
- Views 87
- Downloads 0
NEUROIMAGING IN AFEBRILE SEIZURE IN PAEDIATRIC AGE GROUP
BACKGROUND Seizures are very common in paediatric age group due to immature neuronal arborisation. Many cases present to Casualty with convulsions due to various causes. This study is done to know the importance of Neuro...
A STUDY ON CARDIOVASCULAR MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS
BACKGROUND SLE is a classic prototype for a multisystem inflammatory disease with autoimmune aetiology. Because of the pleomorphic nature of this disease, its cardiovascular manifestations have not always been emphasised...
EVALUATION OF GENE XPERT ASSAY IN EXTRAPULMONARY TUBERCULOSIS IN CHILDREN
BACKGROUND Tuberculosis constitutes the main infectious cause of death worldwide. Extra-pulmonary tuberculosis (EPTB) accounts for up to sixty percent of all cases of childhood tuberculosis. In high burden countries like...
CONSERVATIVE VS. OPERATIVE MANAGEMENT OF LONG BONE FRACTURES IN OSTEOPETROSIS: LONG-TERM STUDY IN 12 YRS. PERIOD
BACKGROUND Albers-Schonberg in 1907 described a rare developmental disease. [1] In 1926, Karshner introduced the term osteopetrosis. [2] Because of diminished bone resorption due to osteoclastic abnormality, b...
LOW BACK PAIN IN PREGNANCY
BACKGROUND Low back pain in pregnancy can be defined as pain between the 12th rib and the gluteal folds/ pubic symphysis may radiate to the posterolateral thigh, to the knee and calf during the course of pregnancy. It ha...