Maternal Changes in Haematological Profile Following Administration of Ethanol Extract of Piliostigma thonningii Leaves on Pregnant Wistar Rats.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
In pregnancy several haematological changes do occur as part of the physiological adaptation of the body to this condition hence some metabolism may be affected. Therefore, this research investigated the effect of extract of Piliostigmathonningii on the haematological parameters of pregnant Wistar rats. The leaves of P. thonningii were collected and air dried for 14 days until constant weight was obtained. Twenty (20) pregnant female albino rats (160-220g) were randomly assigned to groups labeled A-D and treated thus. Animals in group B-D respectively were administered orally 200, 100, 50mg/kg body weight of the extract of Piliostigma thonningii while group A which served as the control received distilled water. The extract administration was done for 14 days consecutively. Thereafter, the animals were sacrificed and blood collected via cardiac puncture for haematological evaluations. The result showed that the extract caused a significant reduction (P< 0.05) on white blood cell count (WBC), monocytes, neutrophil counts and serum platelets compared with the control. However the extract caused a significant increase (P<0.05) in lymphocyte, Red blood cell (RBC),Haemoglobin (Hb) , and packed cell volume (PCV) compared to the control in a dosage dependent manner. It appears when taken during pregnancy, theextract of Piliostigma thonningii leaves may have the potential to act as panacea to anaemic condition or physiological iron deficiency associated with pregnancy.
Authors and Affiliations
Dasofunjo. K, Okwari O. O, Jeje S. O, Ezugwu H. C, Atunka E. A, Onah L. N, Akongwubel, G. A
Keywords
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