MDM2 SNP309 polymorphism in Turkish population
Journal Title: Cumhuriyet Medical Journal - Year 2017, Vol 39, Issue 4
Abstract
Objective: Murine double minute 2 (MDM2) gene has a critical role on regulation of p53 tumor suppressor pathway. MDM2 is a major negative regulator of p53 function. MDM2 protein regulates p53 function through multiple independent pathways. The present study aims to determine the frequency of MDM2 gene SNP309 (rs2279744) polymorphism in the Turkish population. Method: This study included a total of 301 healthy Turkish individuals (159 females (53.0%) and 141 males (47.0%) between 2014 and 2016. The frequency of T309G MDM2 rs2279744 polymorphism was identified using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results: The mean age of the study population was 49,80±16,4 years (51,97±15,98 years in men and 47,58±16,82 years in women). Genotype frequencies for MDM2 rs2279744 polymorphism were found to be 17.9% TT, 55.2% TG, and 26.9% GG. Conclusions: The present study provides information on the allele and genotype frequency distribution of MDM2 gene rs2279744 polymorphism in the Turkish population, which can be used as a reference parameter for the investigation of susceptibility to various disorders, particularly cancer.
Authors and Affiliations
Ayca Taş, İsmail Sari, Tuğba Ağbektaş, Yavuz Siliğ
Keywords
Related Articles
- EP ID EP247372
- DOI 10.7197/223.v39i32356.369012
- Views 96
- Downloads 0
The relationship between I-131 uptake in postoperative residue thyroid tissue and absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels in patients with differential thyroid cancer: A retrospective comparison study
Objective: The aim of this study was to compare I-131 uptake in postoperative residue thyroid tissue and absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels in patients with differential thyroid...
The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis
Objective: Mean platelet volume (MPV) and platelet distribution width (PDW) are parameters that indicate platelet volume. It is assumed that large platelets are enzymatically and metabolically more active than small plat...
Anorectal amelanocytic malignant melanoma: Case report
Primary anal malignant melanoma is a rare tumor of the anal region. Usually it was misdiagnosed as hemorrhoids or anal polyp so delayed diagnosis can lead complicated status of the disease.Clinical and histopathological...
Different presentations of vulvar malignant melanoma: Report of two cases
Malignant melanoma (MM), an invasive and aggressive cancer of the skin, causes distressing mortality and morbidity than other cancers. Gynaecological tract primary melanomas include a class of disorders that develop from...
Domestic violence crimes between 2008-2011 in Turkey
Objective: The purpose of this study; by collecting official data from the Ministry of Justice, analysing trends in time and differences among cities and regions. Method: Criminal data was taken from the criminal courts...