Mean Platelet Volume as Predictor of Sepsis
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Neonatal sepsis is one of the most common causes of NICU admission and one of the major causes of morbidity and mortality throughout the world. Objective of the study was to study organism-specific platelet response and to study mean platelet volume as predictor of sepsis in neonates. Methods and Materials: Neonates admitted to single level-three intensive care units from January 2013 to 2015 were prospectively evaluated for sepsis by rapid screen test, blood counts and blood culture. In thrombocytopenic babies organism-specific platelet response and its effect on various platelet parameters were evaluated. In addition, morbidity, mortality and factors affecting survival were studied. Results: Sepsis was diagnosed in 280 of 1100 (25%) patients. Gram-negative in 58% (161/280), Gram-positive sepsis occurred in 29% (80/280) and fungal in 4% (12/280) of patients. Thrombocytopenia was obtained in 46% (130/280) of babies. Mortality rate was higher in thrombocytopenic neonates. The frequency, severity and duration of thrombocytopenia were more with Gram-negative infection. The incidence of persistent bacteremia, multiorgan failure and death was also more in Gram-negative sepsis. Mean platelet volume was much increased in severe thrombocytopenia, Gram-negative sepsis and in non-survivors and can therefore be used as predictor of sepsis and outcome in neonates. Conclusion: In thrombocytopenic babies with sepsis, organism-specific platelet response is seen. In addition, persistent bacteremia, multiorgan failure and death are more in these babies, and survival decreases with the increased severity and duration of thrombocytopenia. In addition MPV can be used as an early predictor of sepsis and outcome in neonates.
Authors and Affiliations
Altaf Hussain Kambay, Refut Arah, Israrul Haq Lone, Mansoor ul Haq Lone, Ansarul Haq Lone
Keywords
Related Articles
- EP ID EP425055
- DOI -
- Views 106
- Downloads 0
Diabetes Mellitus Complications in India
Introduction: The World Health Organization (WHO) has observed an apparent epidemic of diabetes that is strongly related to lifestyle and economic change and all are at risk of the development of complications. So the st...
Evaluation of Early Laparoscopic Cholecystectomy for Acute Calculus Cholecystitis in Semiurban Setup in Western U.P
Introduction: The common approach for management of acute calculus cholecystitis consist of an initial control of inflammation followed by interval cholecystectomy after a period of 5 weeks. However there is an increased...
Efficacy of Adding Dexmedetomidine to Bupivacaine on Attenuating Hemodynamic Response to Skull Pin Placement for Performing Scalp Block
Introduction: Acute increases in heart rate and arterial blood pressure can be deleterious in the neurosurgical patient with increased ICP or with cerebral aneurysms. So present study was done to evaluate the efficacy of...
Time and Predicting Factors of Non-compliant TB Patients to Default Treatment - A Perspective from Sudan - 2016
Introduction: Tuberculosis is a chronic infectious disease that requiring prolonged course of treatment. The Treatment regimens recommended under Sudan National Tuberculosis Program have shown to be effective, but poor c...
Urinary Stones, Renal Cysts and Renal Impairment in Patients with Gout
Introduction: Urinary stones, renal cysts and renal failure are reported complications of gout. This study aimed to elucidate prevalence and relationship among them in gout patients. Material and Methods: In this prospec...