Mean Platelet Volume as Predictor of Sepsis
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Neonatal sepsis is one of the most common causes of NICU admission and one of the major causes of morbidity and mortality throughout the world. Objective of the study was to study organism-specific platelet response and to study mean platelet volume as predictor of sepsis in neonates. Methods and Materials: Neonates admitted to single level-three intensive care units from January 2013 to 2015 were prospectively evaluated for sepsis by rapid screen test, blood counts and blood culture. In thrombocytopenic babies organism-specific platelet response and its effect on various platelet parameters were evaluated. In addition, morbidity, mortality and factors affecting survival were studied. Results: Sepsis was diagnosed in 280 of 1100 (25%) patients. Gram-negative in 58% (161/280), Gram-positive sepsis occurred in 29% (80/280) and fungal in 4% (12/280) of patients. Thrombocytopenia was obtained in 46% (130/280) of babies. Mortality rate was higher in thrombocytopenic neonates. The frequency, severity and duration of thrombocytopenia were more with Gram-negative infection. The incidence of persistent bacteremia, multiorgan failure and death was also more in Gram-negative sepsis. Mean platelet volume was much increased in severe thrombocytopenia, Gram-negative sepsis and in non-survivors and can therefore be used as predictor of sepsis and outcome in neonates. Conclusion: In thrombocytopenic babies with sepsis, organism-specific platelet response is seen. In addition, persistent bacteremia, multiorgan failure and death are more in these babies, and survival decreases with the increased severity and duration of thrombocytopenia. In addition MPV can be used as an early predictor of sepsis and outcome in neonates.
Authors and Affiliations
Altaf Hussain Kambay, Refut Arah, Israrul Haq Lone, Mansoor ul Haq Lone, Ansarul Haq Lone
Keywords
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