MEASUREMENT OF CADMIUM CONCENTRATION IN BLOOD AND FOLLICULAR FLUID TO ASSESS ITS RELATION WITH OOCYTE AND EMBRYO QUALITY IN WOMEN UNDERGOING INTRA CYTOPLASMIC SPERM INJECTION
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Background: Cadmium, is known to cause opposing reproductive effects, and classified as an endocrine disrupting chemical. Objectives: General population has relatively higher exposure to environmental pollution, the goal in this study is to assess the effect of Cadmium concentration level in blood and follicular fluid on oocyte, embryo quality and pregnancy success in women undergoing ICSI. Patient, Materials and Methods: This study included 70 infertile couples joined in assisted reproductive technology (ART) programs to enter ICSI cycle in high Institute for Infertility Diagnosis and Assisted Reproductive Technologies and Kamal AL-Samarai Hospital, center of fertility and IVF(Baghdad/Iraq) during the period from October 2016 to February 2017. The level of Cadmium concentration will be measured and assess their effect on oocyte and embryo quality. Results: highly significant difference was observed in follicular fluid cadmium (p- value 0.0429, P < 0.05) also there was No-significant difference was observed in blood cadmium(P < 0.05). Blood Cadmium in pregnant there was negatively correlated with (M1, M2, GV, rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer but in no- pregnant group there was positive correlated with (M1,M2,GV,rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer. Follicular fluid cadmium in pregnant group shows positive correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer and negative correlation with GV, rapture and M1 type of oocyte. Follicular fluid cadmium in no-pregnant there was positive correlation with GV, rapture and M1 type of oocyte and negative correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer. Conclusions: There was a Significant difference in follicular fluid cadmium between pregnant and no–pregnant. The Increasing number of oocyte lead to increase the fertilization rate, high number of embryo transfer(grade1) this lead to increase chance of pregnancy outcome.
Authors and Affiliations
Dr. Shams A. Burhan
THE PHYSICOCHEMICAL AND ANTIOXIDANT POTENTIALS OF THEOBROMA CACAO L. SEED OIL (MALVACEAE) OBTAINED FROM SOUTHERN NIGERIA
Theobroma Cacao L. (Malvaceae) is one of the major cash crops of Nigeria that has use in cosmetics, Pharmaceuticals and food industries. While the seed powder is used as herbal medicine for diabetes, cancer and heart dis...
CYTOTOXICITY EVALUATIONS OF THE AQUEOUS EXTRACTS OF HERBAL MELANIN DRIVED FROM NIGELLA SATIVA SEEDS USING IN VIVO AND IN VITRO MODELS TESTS
Background: Many studies over millennia have been carried out to determine a widely used medicinal plant throughout the world. Of these, most of the therapeutic properties of Nigella sativa (N. sativa) seeds are due to t...
QUANTUM ANALYSIS OF THE INTERACTION OF VORTIOXETINE VS. NEUROTRANSMITTERS.
Vortioxetine (Vx) is a drug recently approved by the Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) which is a disease that mainly affects the emotional state of people. The main...
APPLICATIONS OF APTAMERS IN DRUG DELIVERY SYSTEM
Aptamers, a kind of short single-stranded oligonucleic acids (DNA or RNA) or peptide molecules that can fold into secondary or tertiary structures, are well recognized as a potential tool for binding target molecules due...
A STUDY TO INVESTIGATE THE EFFECT OF A BRONCHODILATOR DRUG (MUCOPHYLLINE) ON BREAST-FEEDING ALBION RATS.
This work aimed to investigate the impact effect of the mucolytic and broncholytic drug on the female albino rats during lactation period. The breast feeding rats administered chosen drug by gastric tube from 1st postpar...