Mechanisms of Action of Probiotics based on Bacillus subtilis
Journal Title: Актуальна інфектологія - Year 2016, Vol 2, Issue 11
Abstract
The bacterium B.subtilis is one of the most promising probiotics studied in recent decades. Mechanisms of its probiotic action are associated with the synthesis of antimicrobial agents, increasing of non-specific and specific immunity, stimulation of growth of normal microflora of the intestine and the releasing of digestive enzymes. B.subtilis releases ribosomally synthesized peptides, non-ribosomally synthesized peptides and non-peptide substances with a broad spectrum of antimicrobial activity covering Gram-positive, Gram-negative bacteria, viruses and fungi. Resistance to these antimicrobial agents is rare. Enhancement of non-specific immunity is associated with macrophage activation and the release of pro-inflammatory cytokines from them, increasing of barrier function of the intestinal mucosa, releasing of vitamins and amino acids (including essential ones). Enhancement of specific immunity manifests by activation of T- and B-lymphocytes and the release from the latter of immunoglobulins — IgG and IgA. B.subtilis stimulates the growth of normal intestinal flora, in particular, bacteria of the genus Lactobacillus and Bifidobacterium. Furthermore, probiotic increases the diversity of intestinal microflora. Probiotic secretes all major digestive enzymes to the intestinal lumen: amylases, lipases, proteases, pectinases and cellulases. In addition to digestion, these enzymes destroy antinutritional factors and allergenic substances contained in the food. These mechanisms of action make reasonable the use of B.subtilis in the combination therapy to treat intestinal infections; prevention of respiratory infections during the cold season; prevention of antibiotic-associated diarrhea; for the correction of food digestion and movement impairments of various origin (errors in the diet, changes in the diet, diseases of the gastrointestinal tract, disorders of the autonomic nervous system, etc.). B.subtilis does not usually cause side effects. This probiotic is characterized by a high efficacy and safety ratio.
Authors and Affiliations
A. V. Savustyanenko
Keywords
Related Articles
- EP ID EP211089
- DOI -
- Views 81
- Downloads 0
Clinical Cases of Intestinal Yersiniosis as a Trigger for Collagenosis in Children
A case of severe intestinal yersiniosis, caused by Yersinia enterocolitica 03 and Yersinia enterocolitica 09 as a trigger for the development of dermatomyositis in a teenager aged 14 years old is described.
Nature of the Defeat of the Digestive System in Patients with Drug-Resistant Tuberculosis Using 2nd Line Drugs
The prevalence and nature of the defeat of the digestive system, depending on the profile of resistance to antituberculosis drugs in patients with drug-resistant pulmonary tuberculosis in the Chernivtsi region, were esta...
Meningococcal Disease (Infectio Meningococciea). Part 2
The lecture deals with the diagnosis and treatment of meningococcal disease. Attention is given to laboratory diagnosis, differential diagnosis. There are provided the algorithms of medical care for children with meningo...
Clinical and Paraclinical Features of Atopic Dermatitis Associated with Violations of Intestinal Microbial Landscape in Infants
The objective of the work was to study the diagnostic value of clinical and paraclinical indicators in children with manifestations of intestinal dysbiosis on the background of atopic dermatitis to improve the treatment...
Infectious component of the pediatric acute-onset neuropsychiatric syndrome (PANS) in terms of evidence-based medicine principles (review of literature)
The first clinical cases of obsessive-compulsive disorder and/or tic disorder in children with acute sudden onset associated with infectious diseases have been named pediatric infection-triggered autoimmune neuropsychia...