Mechanisms of Action of Probiotics based on Bacillus subtilis
Journal Title: Актуальна інфектологія - Year 2016, Vol 2, Issue 11
Abstract
The bacterium B.subtilis is one of the most promising probiotics studied in recent decades. Mechanisms of its probiotic action are associated with the synthesis of antimicrobial agents, increasing of non-specific and specific immunity, stimulation of growth of normal microflora of the intestine and the releasing of digestive enzymes. B.subtilis releases ribosomally synthesized peptides, non-ribosomally synthesized peptides and non-peptide substances with a broad spectrum of antimicrobial activity covering Gram-positive, Gram-negative bacteria, viruses and fungi. Resistance to these antimicrobial agents is rare. Enhancement of non-specific immunity is associated with macrophage activation and the release of pro-inflammatory cytokines from them, increasing of barrier function of the intestinal mucosa, releasing of vitamins and amino acids (including essential ones). Enhancement of specific immunity manifests by activation of T- and B-lymphocytes and the release from the latter of immunoglobulins — IgG and IgA. B.subtilis stimulates the growth of normal intestinal flora, in particular, bacteria of the genus Lactobacillus and Bifidobacterium. Furthermore, probiotic increases the diversity of intestinal microflora. Probiotic secretes all major digestive enzymes to the intestinal lumen: amylases, lipases, proteases, pectinases and cellulases. In addition to digestion, these enzymes destroy antinutritional factors and allergenic substances contained in the food. These mechanisms of action make reasonable the use of B.subtilis in the combination therapy to treat intestinal infections; prevention of respiratory infections during the cold season; prevention of antibiotic-associated diarrhea; for the correction of food digestion and movement impairments of various origin (errors in the diet, changes in the diet, diseases of the gastrointestinal tract, disorders of the autonomic nervous system, etc.). B.subtilis does not usually cause side effects. This probiotic is characterized by a high efficacy and safety ratio.
Authors and Affiliations
A. V. Savustyanenko
Keywords
Related Articles
- EP ID EP211089
- DOI -
- Views 86
- Downloads 0
The Incidence of Acute Upper Respiratory Infections of Multiple or Uncertain Localization in Ukrainian Children
The article analyzes the incidence of acute infections of the upper respiratory tract of multiple or uncertain localization among the child population of Ukraine. Some features regarding the level of incidence of these i...
Experience with Deworming in Children
The urgency of the problem of the treatment of parasitosis is not in doubt. The World Health Organization has included the control of soil-transmitted helminthiasis into the Global strategy of development. Our study of...
Comparative Characteristics of the Epidemiological Situation on HIV/AIDS in Two Administrative Districts of Large Industrial City
Relevance. Ukraine is at one of the leading places in Eastern Europe on the prevalence of HIV/AIDS. The epidemic continues with the trend towards further growth in all regions of Ukraine, but spread across the country is...
Rubella: Features of Course in Adults (Clinical Lecture)
For the recent years rubella has become a significant social and medical problem in Ukraine. A high level of morbidity has been detected as well as the proportion of congenital abnormalities in the structure of infantile...
A Rational Approach to the Treatment of Acute Tonsillopharyngitis in Children
In this paper, we consider a variant of the local anti-inflammatory therapy in acute tonsillopharyngitis in children with anti-inflammatory, analgesic effect, both as monotherapy and in combination with antibacterial age...