Mechanisms of beta lactamase production in GNBs from burn wound infection
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Infection is one of the common causes of morbidity and mortality among hospitalized burn patients. Infection by the multidrug resistant bacteria reduces the therapeutic options for the effective treatment. The increasing incidence of beta-lactamase production due to multiple mechanisms in isolates from burn infection is alarming and poses a significant challenge if remains undetected. The present study was undertaken to evaluate the different mechanisms of resistance in burn wound isolates. A total 181 swabs were collected from patients admitted in burn unit from Jan 2013-Dec 2013. Among 134 culture positive swabs 157 isolates were studied for identification and antimicrobial susceptibility testing. All Gram negative bacilli were subjected to detection of Extended Spectrum of Beta Lactamase (ESBL) by predictor disc approximation method. All P. aeruginosa isolates were screened for Metallobetalactamse (MBL) production by Imipenem – EDTA disc diffusion method. K. pneumoniae was the commonest ESBL producing organism. Among 31 beta lacatmase producing P. aeruginosa strains, 21 were MBL producing, 6 were AmpC and 4 were plain ESBL producers. Among 32 ESBL producing Gram negative bacilli (other than P. aeruginosa) 22 isolates were ESBL+Derepressed mutants and 10 were plain ESBL producers.
Authors and Affiliations
Vishakha V Shikhare, P B Palekar, N P Jangle, M N Ramteerthakar, P A Joshi
Keywords
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