Medical Nutritional and Biochemical Role of N-Acetyl-L-Cysteine and its Spectrophotometric Determination by Complexion with RU (III) and Characterization by Elemental Analysis, FTIR, ESR, NMR, TGA, DTA Proposed Structure of the Complex
Journal Title: Journal of Chemistry and Applied Biochemistry - Year 2017, Vol 4, Issue 1
Abstract
Micro determination of the antioxidant, anti-HIV drug N- Acetyl-L-Cysteine was achieved by its complexation with Ru(III) using spectrophotometry, Ru(III) form very light brown colour complex with N-Acetyl-L-Cysteine at rooms temperature max of the complex is 464 nm, ---= 5.62X103 L/mol/cm. Beer’s law range is 7.871 x 10-8 mg to 9.445x 10-7 mg, Job’s method of continuous and mole ration method confirms the metal to ligand ratio as 1:1. Effect of presence of foreign metal ions was also studied, and it was also studied and it was found that 1 ppm of N-Acetyl-L-Cysteine can bear 0.00047 ppm of zinc sulphate, 0.078 ppm of cobalt nitrate, 0.00021 ppm of Nickel sulphate, 0.0038ppm of ferric chloride and Os(VIII), Pd(III) interfere, Characterization of the complex was done by elemental analysis (CHN estimation) which confirms the metal to ligand ration as 1:1 FTIR spectrum of the complex ascertain the binding of sulphur atom and NH2 group. 1H NMR spectrum of the complex exhibit a disappearance of SH peak and NH peak hence confirming the binding of sulphur and nitrogen atom with Ru(III). Three ESR signals show paramagnetic nature of the complex. DTA, TGA confirms the presence of lattice and coordinated water molecules.
Authors and Affiliations
Sharma KP
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